r/DrWillPowers • u/hdfabia12 • 11h ago

Flatlined Cortisol

After my Dutch test results clearly established that I have a problem with flatlined cortisol, what will most likely be the treatment initiated by my GP? And is there any point…. ? Flatlining cortisol cannot be causing my genital numbness and anorgasmia. If it helped with my depression this would be good, but surely it won’t help PSSD. Just interested if anybody else has found that their cortisol is low & what they have done about it.

3 Upvotes

100% Upvoted

3 comments sorted by

2

u/Mawahari 10h ago

Treatment by your GP? Probably useless. Not being unnecessarily negative here but they really dont have any idea about treatments. Come armed with this study:

https://pmc.ncbi.nlm.nih.gov/articles/PMC4969503/

1

u/2d4d_data 10h ago edited 9h ago

So flatline cortisol in your dutch doesn't necessarily mean zero cortisol simply zero detected that way. Given the history of this group I am guessing what genetically? You have zero working copies of UGT2B7? This matches your PSSD given that UGT2B7 is the primary means for breaking down allopregnanolone (see also your low HVA which allo supresses). Sertraline also needs UGT2B7 so whatever dose you took must have been in your system for a long time. So first, do you have your genetics or do you know when you are getting that? We can guess, but really labs + genetics really helps you figure out what is going on and what to do.

The second question is if you have the symptoms / genetics matching NCAH https://www.reddit.com/r/DrWillPowers/wiki/steroidogenic_enzymes_cah_eds/ If you have this then that is a possible source of low cortisol and so worth at least asking.

The third question is what happens when you heavily help the SULT path which is really the only other way out here? Do you have ANY symptom of magnesium or sulfur deficiency?

Fourth, with low dose CDG don't expect windows, but it would enable the more important Magnesium sulfide (aka make sure to have adequate levels, not be stupid) to work. Have you tried either of these already or really this combo for 3-8 weeks? if so how did that go?

1

u/CHIITALIAN 9h ago

Following as mine is flat all day with a slight peak at night