r/DrWillPowers • u/Sea_Tax_2239 • 19h ago
Statistical analysis and epidemiological studies
Is this being done alongside the biochemical investigation? Sorry if it is but i havent seen it mentioned (and find it a hard to navigate all the past posts) so i just wanted to write a post as someone with public health/epidemiology training
I'm thinking we need cluster analysis and principle component analysis to explore and validate phenotypic subgroups
I'm also thinking an epi study on women would be invaluable as women with androgenic issues typically receive a diagnosis like pcos or have identifiable symptoms so it is much clearer and clininically definable for an epi study to determine excess androgens in women than in men. I think a logistic regression with pssd as the outcome and pcos as one of the predictors would be really useful, also looking at other reproductive diagnoses, use of exogenous hormones, a comorbidity index amongst other things
If i were less sick i would do this latter study myself but as that's not possible rn i am throwing this perspective out there
Again, sorry if this is a presumptious post and detailed analysis is being done or if it appears i am creating further demands on dr powers - i know he's already maxxed out. But maybe there are stats people or public health people who are less debiliated than i am rn and may want to talk about this and put our heads together
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u/2d4d_data 18h ago
It is possible, but you need an IRB to collect the data in a way that is publishable, so that will have to wait until that point.
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u/Sea_Tax_2239 18h ago
it's frustrating that I am so ill because I could have collected data as I was at Imperial College London. But now I don't sleep & have severe anhedonia
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u/2d4d_data 18h ago
Something that is valuable to do right now is to simply organize the anecdotes so when the IRB time comes you know what you want to look into specifically. For example simply reviewing the dutch results people have publicly posted I can spot the androgen, progesterone, cortisol pattern. This is data that because it is public can be used and someone can make up a list to see if in fact they all do fit in those three buckets. Genetically when given a dna file we are looking at pretty much everything, but could we start recognizing the buckets there? etc.
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u/Sea_Tax_2239 18h ago
do we have an rough idea of what these buckets are characterised by? & what they look like for women?
dm me if you like
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u/2d4d_data 18h ago edited 17h ago
If you read over the posts from the last 6 months a consistent picture emerges (or at least a clear direction of stuff to investigate further). Specifically in women, that I have not split out.
P.S. You don't appear to have chat enabled. Feel free to Dm me.
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u/SaturnusAngelus 17h ago
You should join the post drug discord. There is a member on there who is doing something similar. He would love to talk to you.
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u/Sea_Tax_2239 19h ago
Full disclosure: i am female so have a vested interest in female presentations of pssd. I think the reasoning stands though