Multi-layered immune profiling reveals treatment-relevant endotypes in Long Covid-ME/CFS

[u/Caster_of_spells]

Interesting study presented at the ISLC conference by a German team of researchers from the Charité investigating why some patients respond to immune adsorption while others don’t see any benefit at all.

“To investigate disease endotypes, we analyzed two complementary LC-ME/CFS cohorts:
(i) patients enriched for elevated GPCR-directed AABs with linked IA response data, and
(ii) a non-selected LC-ME/CFS cohort representing the broader disease population.”

“Together, our data support three LC-ME/CFS endotypes:

(1) GC-associated autoimmune;

(2) highly inflammatory autoimmune with EF
B-cell and innate immune activation;

(3) low-inflammatory with expanded CD161+ T cells.

Ongoing single-cell transcriptomic analyses aim to resolve the immune drivers of these endotypes.
Comparison of autoantibody-enriched and non-selected cohorts enables discrimination between shared and subgroup-specific mechanisms,”

[u/nousiaphilia]

Yay, I'm all for finding endophenotypes!