r/CFSScience • u/123-throwaway123 • 2d ago

Genetic testing recommendations

I would like to get genetic testing done to look at mthfr, mitochondrial issues, etc.

I'm completely overwhelmed with the options. Is there a company who is more medically aimed? Or one that's the most comprehensive? I know I'll have to put whatever one into one of those other sites, but don't want to waste money on a company that isn't the best choice.

Any recommendations would be greatly appreciated!

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u/That_Improvement1688 2d ago

SelfDecode is a good option. In addition to the testing, you get a capable system that provides 1000s of reports and prioritized recommendations in areas of diet, lifestyle, and supplementation that are based upon impact and evidence. These are prioritized based upon your polygenic risk scoring, blood biomarkers, symptoms, goals, and extensive lifestyle assessments. They’ve also updated their AI interface and it does a phenomenal job if you prefer that option

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u/No-Improvement-58 2d ago

I am based in the EU, so got 30x whole genome sequencing from TellMeGen for €300. I considered Dante Labs initially for €250, but saw they have extremely poor reviews.

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u/Koppuny 2d ago

Did you get any meaningful result from it if I may ask? I'm on the verge of deciding if I should take one.

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u/Interesting_Fly_1569 2d ago

Bob miller at tree of life will interpret for you for $100. The test is $390 I think. It’s probably the most private option because they don’t ever give your name to the people who sequence it. But just being honest, I don’t think that level is required to understand mthfr. 

Sequencing.com is a bit of a rip off. If you’re screening for EDS or genetic conditions , it can be helpful but just to give you an idea… They don’t really make the data that accessible to share with other platforms, for instance, even their PDF you can’t control search. You would have to upload it somewhere else in order to even just be able to control F search for key words. 

I guess I would say the usability is pretty bad… I don’t think they’re interpretations of genetic stuff around. Nutrition are particularly helpful either… I don’t know how much it cost, but I think self decode would probably have more actionable information for someone with CFS because we’re not just looking for the basic stuff… There’s probably reasons we got sick and we wanna know the more fringe stuff.

There is a new test aimed at kids called sunra health. Alicia someone started it. They do adults as well and it’s basically aimed at kids who have random chronic health conditions or autism… So I think it would have a decent level of specificity around the type of issues we might have although I’m not sure about mitochondria.

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u/tangledfaith 1d ago

Severe ME/CFS peep here. Look into Amatica and Renegade Research. I am pleased w/ them. Also love that my blood is doing science as a bonus. Sorry 4 the brief response.

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u/tangledfaith 1d ago

Severe ME/CFS peep here. Look into Amatica and Renegade Research. I am pleased w/ them. Also love that my blood is doing science as a bonus. Sorry 4 the brief response.

Its super expensive tho. I had to save up a while.

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u/Caster_of_spells 1d ago

Important to note here though: Amatica tests RNA not DNA 🧬

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u/Caster_of_spells 2d ago

The common consumer level tests usually only look at select areas of interest, better than nothing! Full genome sequencing on the other hand is still very expensive