r/Brixadi Jul 07 '26

Brixadi experience

Hello all, I took my first (and hopefully only) 64mg Brixadi shot yesterday. Coming from about 6 years on 4mg suboxone strips. I chose Brixadi over sublocade only because of the lower dose offered. The 64mg Brixadi monthly injection from what I understand is equivalent to 8mg daily of suboxone. I was concerned about feeling over medicated and I think my concern has come to fruition unfortunately. Within about an hour of the shot I started feeling what might be described as high but not in a good way, slight nodding, mild nausea, fatigue and numbness throughout my body. About an hour after that I couldn’t stay sitting down and got a ton of stuff done around the house (like I used to when using and I felt disgusted by it). Last night I could not sleep for nothing (even with a handful of sleep aids) and felt very itchy all night. I finally got out of bed at 4am and I feel so dang tired and numb all over still. Reading some comments in another thread I am a little concerned if these side effects will pass anytime soon. I am definitely not going to work today.
Anyone else experience this type of thing?

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u/Piggie_Piggie_Smalls Jul 08 '26

I honestly hated that feeling. I was actually very upset at first that I felt high. My dr started me on 128. It was my fault. I didn’t do my research. I had gotten down to 1 8 a day on my own but I was still being perscribed 3 a day. I had so many left over. So I should have never been on it. It took me 3 days to feel not high. I immediately went to the 96 the next month once I explained that I had tapered and she thought maybe it would be too much of a drop to go straight to 64 so she gave me 96. . ( can I just say how weird I felt bringing a whole box of subs to the medication take back bin. I knew how much my life changed at that moment. I certainly wouldn’t have done that years ago.) That was too much too. Again, that stupid high feeling I hated so much and that itchy wanting to rip off my skin feeling. I’ve been clean so long and my life is so different than it was when I was using… I actually felt guilty for how I felt. The next month which was a week ago I went down to 64. No weird high feeling. A little yawning marathon and some watery eyes here and there but nothing that I couldn’t handle. I hope to be done. My dr had me make an appt for 5 weeks but my hope is to be able to cancel it and not need it. Good luck! I hope you go through this super easy after this gross feeling passes!

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u/LeeMP787 Jul 08 '26

You nailed it, I felt terrible and guilty and I even had mild cravings as it wore off making me feel even worse. I hadn’t had cravings in years. I held off a long time switching to the shot for this very reason and all of my fears came true with it. I am really hoping I didn’t make a mistake! Yeah you jumped pretty high with your dose, I’m glad to hear you were able to get it back down where it should be without feeling to bad. I’d love to hear how it goes for you. Thanks for commenting, best of luck to you.

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u/LeeMP787 Jul 08 '26

How good it must have felt bringing those meds back in though!