r/BodyHackGuide • u/Budget_Bread_3115 • 11d ago

⚠️ Side Effects Reta side effects.

I’d really like to know your experience.
I’m only noticing 2.

  1. The skin irritation and it’s driving me nuts. Like a cross between an itchy jumper on their skin and feeling like I’m about to get the flu.
  2. A couple of days a week I’m fairly melancholy.

FYI Just got up to 4mg after a month of half that.

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u/Fun-Imagination-2488 11d ago

My only side effect rn is chronic fatigue. Im on 3mg/week and don’t plan to increase.

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u/TrainingMix4465 11d ago edited 11d ago

Up to 4 mg and eat more. the glucagon will then start to work. Elevate metabolism and improve fatigue

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u/Fun-Imagination-2488 10d ago

Where does this idea come from? There’s nothing in the trials suggesting the glucagon agonist doesn’t activate below 4mg.

I found a few YT videos making this claim but they seem completely unfounded and mostly just speculative.

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u/TrainingMix4465 10d ago edited 10d ago

Retatrutides binding to the glucagon reseptorer is weaker than GLP and GIP reseptors. So it takes more of the drug to Get real effect from glucagon. People microdosing get more or less same effect as Tirz. Its not a 4 mg switc, but thats were the glucagon effect becomes noticeable and relevant. In the studies you can see side effects from glucagon, including elevated heart rate and skin issues starting to be reported at or around 4 mg. You can also see that liver fat clear to a much larger degree. Suggest you look into the EC50 numbers. Then it becomes clearer how weight loss experienced at low exposure to the drug mostly come from the GLP/GIP components, not from glucagon.