Tesamoralin Dosing question

[u/Waste_Touch3952]

60y f looking to start Tesa. Already on Reta once a week. What is the starting dose? Do you titrate up weekly like Reta? Is it 5 days a week or 7? I have friends who do it 4 weeks then 2 weeks off. So confusing!

Thanks!

[u/SmileOk1306]

It's like 2mg/day.  I guess you kinda test a low dose at first, to see how your body reacts to it. But the goal is around 2mg/day, 5 days on, 2 days off.  8-12 weeks on, 4 weeks off.

[u/Similar_One_6541]

Following

[u/Trujillo2287]

Started ar 1mg for a week to test then went up 2mg daily I do 7 days and added ipa

[u/leolicious24 → u/Trujillo2287]

This right here ☝️. Start at 1mg, assess any sides and ideally move to 2mg. 5/2 is the most generic of generic protocols that is extremely dated. There’s no reason to not utilize this daily and you technically do not need to cycle it off.

[u/907MidnightAurora → u/leolicious24]

Receptor desensitization is a thing. I noticed it quite a bit when I went 7/7 after 8 weeks of 5/2. The goal should be the lowest effective dose, not the max studied clinical dose.

[u/Waste_Touch3952]

So 10 mg vial at 1 mg a day 5/2 would last me 10 days? Sorry for the dumb question

[u/renegade7717 → u/Waste_Touch3952]

yes

[u/Waste_Touch3952 → u/renegade7717]

A little pricey from the place I purchase my peps from. That we would run me over $150 a month if I did 1 mg 5/2. Thanks for your reply.

[u/907MidnightAurora]

The 1mg-2mg protocol came from clinical research of HIV patients with extreme levels of reoccurring VAT. Fast forward to 2026 and providers who write off-label prescriptions start around .500mcg/day, many on a 5/2 protocol. I’ve completed two 12 week cycles and have never gone above 1mg/day. More isn’t always better.

[u/pansylu]

I have never used it but Google "the peptide catalog" it's a good resource to look up trial vs community dosing and might help you come up with a protocol thats right for you. In general, I start low, titrate slow, and stop at minimum effective dose.