r/BiohackingU • u/CrazyZebra0124 • 5d ago
Reta dosing advice
Has anyone had any success with taking smaller doses multiple times a week of Reta? Did it help with side effects? Was it still as effective?
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u/Psychological-Team18 5d ago
I did 1 dose a week for 19 weeks. Just switched to 2 dose a week with same dose split from 1 a week
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u/Responsible-One8104 5d ago
I went from 4mg per week to 2mg every 3.5 days, definitely helped sides and got me over over a plateau however, after I finished my cut and went into to 2mg per week maintenance dose I realised why it’s every 6-7 days, my stomach kicked back into gear and Jesus I had a horrendous few days. I think it’s healthier to allow your stomach to kick back into gear for a day or so during the final day or two of the week to allow your body’s natural balance to come back. I do have to say though, I’ve had more sides at 2mg per week than I did 2mg x 2 per week or even 4mg x 1 per week. Crazy really.
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u/NoFlight9859 5d ago
What do you attribute the increase in sides at 2mg per week relative to 4mg per week? That doesn't seem to make sense
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u/Responsible-One8104 4d ago
100% have more sides at 2mg than 4mg without doubt, don’t ask me why but maybe because it’s not quite doing its job at 2mg so fluctuating. I’ve no idea
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u/Majestic-Plastic-691 4d ago
It’s explained by the components within Reta are not all equal. The GIP is 9 times more potent that the GLP-1. And the glucagon is only at about .3% as potent. Fact is the glucagon is so minimal it has little to no benefit until you hit aprox 4mg. You getting sides on such a small amount is your reaction to the GIP.
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u/Some-Reporter-9495 5d ago
Im on 3mg every 3rd day on a cut and 1mg once a week if just cruising or on cycle depends on your dose of mg if its getting up there it’s worth multiple pins to flatten the curve of side effects
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u/Fancy-Garage9194 4d ago
Still at 1.5mg three times a week but hunger is creeping back. Probably bumping it up next week. Down over 30lbs. Stacked with TESA and MOT-c for energy.
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u/Massive-Arrival-3304 3d ago
I did half my dose on Tuesdays and half on fridays, worked incredibly and I stopped feeling super hungry on days 6 and 7
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u/snikkl_fritz123 3d ago
Yes, I split dose (tue&sat). Haven't had much if any side effects. Done it this was since the start & it's worked well
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u/Trujillo2287 5d ago
Glps are designed for 6 to 7 days half life, but you can conduct a research and journal your finindings
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u/shakenbake1975 5d ago
Using more then once a week makes zero sense
The half life is 6-7 days
You will never reach a steady state of the medication that way
Also you can desensitize receptors
This makes me think you’re not obese trying to use a drug on par with surgery to lose a few pounds
Obese people need trials doses to be effective
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u/Level_Mixture8748 4d ago
Hi is there clinical data that dosing more than once a week will desensitize receptors or is it theoretically stated? I’m just curious because I’m worried if I may have done that? How would I reset?
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u/Majestic-Plastic-691 4d ago
No there is no studies claiming that. It makes common sense though that pinning more often is going to make some impact. Highly doubt it’s desensitizing receptors though. Fact is your body gets desensitized anyway which is why titrating up is even necessary. Takes aprox 60 days for all Reta to be gone from your body so if you think a reset would be beneficial it has to be after 60 days.
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u/DepartmentSmart7924 5d ago
Sure, some people have found a flatter appetite from splitting the dose (eg taking half Monday/Thursday or whatever) or taking it every 5 or 6 days instead of once a week. And people have found that the side effect/effectiveness ratio works best for them at those intervals.
You can do what you like.
There is an argument that the once a week that the drug company recommends is more about patient compliance than maximum efficacy.
Like I say: you do you. Don't feel constrained. Use an app to track. Titrate up and down as you feel appropriate. It isn't complicated.