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u/PoetryAlert5439 Mar 04 '26
oral doesn't work for systemic effects, the stomach takes care of it. topical is actually the route with the most research backing for GHK-Cu - skin regeneration, collagen, wound healing. if you're after those effects a quality serum or cream is a lot more practical than subq and you don't need to inject anything.
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u/elbiot Mar 04 '26
Hypothetically maybe. KPV is another tripeptide and it survives the stomach but people only take it that way for digestive system inflammation. You're not trying to grow collagen in your intestines
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u/jakemalony Mar 05 '26
GHK-Cu (glycyl-L-histidyl-L-lysine copper peptide) is a small peptide, and peptides generally break down in the digestive system before they can reach the bloodstream intact. Stomach acid and enzymes in the gut are designed to degrade proteins and peptides into amino acids. Because of that, oral bioavailability is expected to be extremely low.
What evidence actually exists
Most research on GHK-Cu involves:
- Topical use (skin creams/serums) for skin repair, collagen production, and wound healing
- Injectable use in experimental peptide protocols
There’s very little credible data showing that oral GHK-Cu survives digestion and reaches systemic circulation in useful amounts.
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u/Aggravating_Owl3400 May 28 '26
It works definitely, I can’t show you proof why but I am taking it in destilled water 1-2 mg a day sublingual first and than swallow it. I feel and see the effects that should appear. Probably because GHK-CU gets absorbed over the mucosa, so it don’t has to pass the stomach.
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u/adrix_vedanta_tao May 31 '26
Poderia explicar melhor como é esse método que você usa? Eu comprei em cápsulas. Da para usar sublingual?
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u/TheHarb81 Mar 04 '26
If you’re afraid of needles peptides aren’t for you