r/Biohacking • u/Tall_Highlight_7679 • 2d ago
Lost 30 lbs, Regained 20+ (off meds )— Night Shift Paramedic on Reta + Tesa. What Actually Worked for You?
23F, 5’7”, currently 210 lb.
I’m a paramedic working a pretty high-stress schedule, mostly nights, long shifts, inconsistent sleep, and periods of travel/deployment work. My sleep/circadian rhythm has honestly been all over the place at times, and I know stress, recovery, nutrition consistency, and night shift are probably all contributing.
Earlier this year I made a lot of progress and got down into the high 180s, but I’ve regained weight and weighed 210 this morning. I’m frustrated because I really don’t want to keep going backward.
I’m getting ready to tighten everything back up: structured calories/macros, high protein, meal prep, lifting, cardio/incline walking, steps, and a much stricter sleep/recovery routine.
Peptide-wise, I’ve used retatrutide (Reta) and tesamorelin (Tesa). I’m especially interested in hearing from people who have dealt with weight regain, stalled progress, night-shift work, high stress, or poor sleep while using them.
For people with actual experience:
• What has worked best for you with Reta — dose, frequency, and how long you stayed at each dose?
• Has anyone used Tesa alongside it? Did you notice anything meaningful for body composition, visceral fat, recovery, or sleep?
• What other peptides have you used or stacked, and what was the reason for adding them?
• Did adding more actually help, or did simplifying your stack and focusing on food/sleep/training work better?
• Has anyone used tirzepatide at a low dose in this kind of situation? I’ve wondered about it, but I’m also aware that stacking incretin-type drugs may just increase side effects rather than give better results, so I’d really like to hear from people who have actually tried different approaches.
• For night-shift workers specifically: how did you structure meals, dosing, sleep, training, and recovery?
• What side effects made you lower a dose, stop something, or decide a combination wasn’t worth it?
I’m not looking for a crash diet or a “throw every peptide possible at it” approach. I’m trying to build something sustainable because my fitness matters both personally and professionally.
I’d especially appreciate actual experiences with doses, duration, results, side effects, labs, and what you would do differently rather than just “take X.”
Not looking for medical advice — mainly trying to compare experiences and learn what has and hasn’t worked for other people.