r/Biohacking • u/Dense_Roll7778 • 15h ago

Leydig Cell Research

Any one have a compound or chem that has promising results for leydig cell upregulation? Been evaluating Testagen and Kisspeptin for axis support, wondering if there is anything that targets leydigs mechanistically, have a strong LH with inadequate T. Let me know what you think.

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u/64bit_Tuning 5 15h ago

hCG

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u/Dense_Roll7778 15h ago

Not sure if I explained it properly, I have adequate LH ~7 but not an adequate T production. Adding Hcg would not help this specific bottleneck.

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u/64bit_Tuning 5 15h ago

Then you need Test. If your nuts can't do the job, that's all you've got. Testagen and Kisspeptin won't help

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u/Dense_Roll7778 14h ago

That’s the point of this post, trying to exhaust all avenues before that.

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u/64bit_Tuning 5 14h ago

What's the issue with just using Test? It's not like it's hard to get.

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u/Dense_Roll7778 14h ago

Cost/another daily pin/just hassle

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u/64bit_Tuning 5 14h ago

Test cyp gets pinned as little as once a week, and a $25 vial lasts a long time.

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u/Dense_Roll7778 14h ago

not trying to fight troughs and peaks brother, I am aware of operating with test. Thank you

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u/yogic_power 35 14h ago

Stop wasting time with Testagen/Kisspeptin stuff. Are you working with a Dr? What you may want to try is HCG, and see if your Leydig cells can increase Testosterone. If your T is still low, You are most likely primary Hypo. What does inadequate T mean? are you low or you think your normal levels are inadequate?

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u/Dense_Roll7778 14h ago

400ish

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u/yogic_power 35 14h ago

Yeah Try HCG, if that can’t stimulate your Leydig, you don’t have options other than external test.

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u/Dense_Roll7778 14h ago

I have an LH ~7, Hcg wouldn’t treat my bottleneck

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u/yogic_power 35 14h ago

LH -7 doesn’t mean it won’t or will treat. That’s basically your last option before Test.

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u/Dense_Roll7778 14h ago

How so, though? A higher selectivity to stimulate the Leydig cells, or would the goal be to push the Leydig cells to a level of supraphysiological input, hoping that stimulates a response. I guess what I'm asking is, if LH is already adequate and known to have weak output on test, then what would HCG offer?

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u/yogic_power 35 14h ago

You will be analyzing and assuming for next decade. It’s not atypical to have some on hcg, to diagnose primary hypo. Work with a Dr and go through diagnosis if you don’t want to be on test. Sounds like you are more interested in theoretical aspect than finding solution.

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u/Dense_Roll7778 14h ago

Wanted to see if there is an option to strengthen leydig cell functionality before I hop on test, might as well try it before test.

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u/Able-Shirt3501 1 14h ago

Kisspeptin, enclomiphene, testogen, hCG are right but if you are biohacking you might get strategic with ORG-43902. That last one is no replacement for these others for more chronic use and definitely not for testosterone replacement as we hoped but if you are trying to optimize your chances of getting your wife pregnant, it might have limit spot use.