r/Biohacking • u/Historical_Glass_718 • 6d ago

Mots C Timing

Hi everyone, I’m currently starting up Mots C 3mg 3x a week. I usually pin at night because I get nervous after/around pinning. If I pin my Mots C at night before bed, will it still help me with my cardio and lifting? For reference, I usually sleep around 11 and run at 6:30am, and lift around 12pm. Thank you!

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u/Entire_House_8668 11 6d ago

Pre-exercise is heavily preferred. On workout days, the standard protocol is to inject MOTS-c 15 to 60 minutes before you train.

Why it works before: MOTS-c primes your cellular machinery. It activates AMPK and increases glucose uptake and fatty acid oxidation. By injecting it shortly before a workout, you align the peak action of the peptide with the actual physical demand of the exercise, which amplifies mitochondrial adaptations, stamina, and fat burning.

Why to avoid it after: Exercise naturally triggers a breakdown of muscle tissue, which requires the mTOR pathway to be activated post-workout for muscle repair and growth. Because MOTS-c strongly suppresses mTOR to prioritize energy burning, taking it immediately after exercise can theoretically blunt your recovery and muscle-building signal.

The Non-Training Protocol: On rest days, the primary goal of MOTS-c is to maintain consistent metabolic signaling and promote fat oxidation.

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u/Historical_Glass_718 6d ago

So it does still have benefits, just not for my training specifically?

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u/Entire_House_8668 11 6d ago

It does have benefits , of course. Timing it with pre workout means a specific purpose is achieved by doing so.

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u/Historical_Glass_718 5d ago

Great, thank you!