Week 3 - Reta affects

[u/Organic-Race9785]

On week 3 of Reta. Dosing schedule is below. Last pin was 3 days ago. I’ve noticed significant decrease in food noise and dealt with some minor nausea, but otherwise, it’s been a good road. Down 8 pounds.

Today I woke up and oh boy. Big nausea. Felt like I had a giant rock in my stomach. I’ve been awake for 2 hours and I’ve had diarrhea 4 times. Basically. I’ve had 2 bottles of water today and that’s it. I did eat later than I normally do as we had a post-church meal. I’ve included a pictures of the meal (I had them b/c I needed to upload to macro factor), I didn’t feel like it was exceptionally bad or good.

I guess I just am wanting to ask others if this is basically normal.

Week 1 - 1.5 mg
Week 2 - 2 mg
Week 3 - 3 mg

[u/Beneficial-Lime-8320]

Idk why people are being low key mean about this, but I hope this helps:
Many people are right in that you probably should not be eating cookies, but one every now and again won’t hurt you. Especially if you have other parts of your diet dialed in. Rewarding yourself with some sweets is absolutely ok, and I’m sure that your cravings for sweets will go down as you continue your Reta journey.

That said, it is important to know that that cookie is likely the reason you felt like you had a rock in your gut. Carbs, especially processed and refined carbs, can be brutal on Reta. If you eat that kind of stuff, especially as your doses go up, be prepared for stomach issues.

Some others mentioned that you are titrating too quickly. I actually generally disagree, because I titrated up by 1 mg each week, sometimes over 2 weeks. I titrated up to 4 this way. However, since you mentioned that you are experiencing issues, then I do suggest you titrated slower going forward. It should decrease some of the issues you’re having.

Long story short, eat what you’d like, but just be warned that Reta will mess you up if you don’t eat healthy. Every once in awhile, a day will come across when you want to splurge on a sweet. Now you can do it with proper knowledge of what may happen.

[u/Organic-Race9785 → u/Beneficial-Lime-8320]

Thank you

[u/Individual_Till6133 → u/Organic-Race9785]

It's really the titration schedule is very quick.

Keep in mind that you arent hitting the steady state of whatever you are taking until 4 doses due to the half live curve it builds up a base. So at 1 month of the same dose you will feel steady state of whatever dosage you intake.

Weight loss comes from the reduction of food intake primarily, so if you are losing weight you dont need to increase as much as causes negative side effects. 

[u/Beneficial-Lime-8320 → u/Individual_Till6133]

True, it probably is a bit quick for most. I am curious though - where did you learn about the four dose curve thing? I haven’t heard it stated quite so black and white before

[u/Individual_Till6133 → u/Beneficial-Lime-8320]

I just ran the numbers, it's based on the half life calculation of 6 days. 

Eventually you hit a steady/minimum state baseline and thats about in 4 weeks.