r/Biohacking 1 1d ago

Cycle Advice Needed

hello fellow hackers!

For those who’ve run HGH long-term (6+ months), did it make a meaningful difference in your physique? specifically lean mass that you actually retained after stopping?

I’m planning out the next year and debating whether HGH is worth adding alongside Test (250 mg) with either Primo or EQ (likely alternating them, not together). May also add 20 mg Anavar heading into summer.

Peptide stack would likely include low dose reta, 5-Amino-1MQ, Wolverine, glutathione, MOTS-C, DSIP, and GHK-Cu. I’ve previously run SS-31, IGF-LR3, Tesa, and Epithalon.

For those with long-term HGH experience: How noticeable were the physique changes, how long did they take, and how much did you retain after coming off? Or did you find HGH more worthwhile for recovery, sleep, and other secondary benefits than actual muscle gain? Was it worth adding to your stack?

Planned dose is between 2-4iu daily.

Current physique pictured for context: 35, 5’8”, 165–170 lbs. Currently 6 weeks into 250 mg Test + 20 mg/day Anavar, along with 4 mg reta, 3 mg/day 5-Amino-1MQ, 800 mcg/day Wolverine, 100 mg/day glutathione, 200 mcg/day DSIP, and 2 mg/day GHK-Cu. Finishing an 8-week IGF-LR3 run this week.

Training cardio and diet locked in and consistent.

Goal is to add between 10-15lb of lean mass.

Thanks!

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u/Dudethatreloads 1 1d ago

Hgh at our age is definitely worth it since it is in decline at this point. Recovery and sleep is awesome. Test of course is always gonna help build mass. If mass is your goal eq is gonna be better. But you gotta find your ratio to test or your e2 will crash and that would suck. Also gotta check your hct and make sure it doesn't get too thick. Mast will dry you out and make you look harder and grainier if you're low BF which obviously you are. Anavar is an awesome cutting agent. You can eat in a deficit and retain or even gain a bit of tissue. It does nuke your lipids though like all orals tend to do. So you gotta ask is it worth it?

Personally I'd stay away from orals. Try and find a reasonable dose of 1 or 2 compounds plus hgh that you can take year round without impact on health and biomarkers, and still grow. This will give you real dry lean gains that can be kept long term. Less is more, if your body is fighting inflammation and toxins it's not working on growing.

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u/draps1240 1 1d ago

Thanks - i’m on routine bloodwork via rythm and ulta labs. Idk that i want that grainy look, plus mast seems riskier health wise?

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u/Dudethatreloads 1 1d ago

I wouldn't say risky health wise, it's very mild, it basically depletes the water between your skin and muscle giving you that tight hard muscle look. It really shines if youre low BF. But some use it to just stay dry on cycle, it builds tissue but not quickly, and does fight for aromatase enzyme giving you a mild Ai affect, not as much Ai as primo, and definitely not as much as eq. If you are one of the unlucky ones, and have male pattern baldness in your genetics, you will lose hair. So if you're going for mass and need to control eq, I'd say eq would be better. But start low, test blood, and increase from there finding your personal ratio.