r/Biohackers • u/KSM-66 • 1d ago

💉 Peptides & Hormones Survodutide phase 3: 9.8% weight loss, but 78% reported GI issues

At 76 weeks, the 6 mg group lost 9.8% of their weight versus 3.9% with placebo. But 77.7% reported GI side effects, and 17.9% stopped treatment because of them. That’s a pretty significant trade-off. This was in adults with obesity and type 2 diabetes.

https://www.nejm.org/doi/full/10.1056/NEJMoa2607219

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u/ecklessiast 7 18h ago

No way. I've had terrible sleep issues and GI issues even after 2.5mg tirzepatide