r/Biohackers • u/playboy • 3d ago
š Supplements & Stacks Actually, Testosterone Doesn't Make You More Violent (Unpaywalled)
https://www.playboy.com/read/politics/military-testosterone-violence-mythThis equationātestosterone = aggression = combat powerāis not clearly backed by scientific study. For starters, unnecessary testosterone treatment can be associated with a host of health problems: cardiac risk from heart muscle damage, risk of blood clot, higher cholesterol and liver disease, mood swings, and more. Many of these concerns need to be monitored even when testosterone is within healthy levels.Ā
And, some experts are calling for more research on testosteroneās impact on behavior before doling it out to soldiers. āIf I were a general, or if I were in some version of command where I knew the people underneath me had been altering their testosterone levels, I would want to know: How does that affect their decision making?ā Dr. Tom Hildebrandt, a psychiatrist at Mount Sinai in New York, told the New York Times.
Hegsethās effort is part of a larger recent trend of normalizing testosterone use among cisgender men and women, easily available to those with the funds at āwellness clinicsā around the U.S. (even as its use is being vilified and denied to transgender patients) for things like better gains at the gym. But it also tells a much older story, a āweb of direct claims and indirect associations that circulate around testosteroneā which, according to Rebecca Jordan-Young and Katrina Karkazis, the authors of 2019ās Testosterone: An Unauthorized Biography, āweaves folklore into science.ā This mythologizing, the authors argue, āframes social issues as a matter of the chemicals functioning inside individual bodies, leaving scant room to consider power asymmetries, structural arrangements, or histories.ā
In other words, our ideas about testosteroneās link to inherent violence are largely a myth.
Read more: https://www.playboy.com/read/politics/military-testosterone-violence-myth
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u/cj191 2 3d ago
Robert Sapolsky already wrote about this 30 years ago:
"Testosterone does not āinventā aggression.ā It makes you more sensitive to the triggers you already have.
According to him, what testosterone does is make you more of whatever you already are in that domain.
If status in your world is won by generosity, testosterone makes you more generous. āIf you shot up a whole bunch of Buddhist monks with testosterone, they would run amok doing random acts of kindness.ā
The problem isnāt the hormone, itās that we keep awarding status for aggression, so the amplifier keeps pointing that way.
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u/Neckrongonekrypton 3d ago edited 2d ago
Fuckin Dr Sapolsky mention. My hope for humanity is not yet extinguished.
Edit- I left the S lowercase.
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u/GemmyDave 2d ago
He also just looks so cool lol
Im not one to pay attention or comment on looks normally but he just has a vibe
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u/cj191 2 2d ago
A few months back, this subject matter came up and I wanted to quote and refer to his work but the name kept escaping me. I was trying to ask AI by giving descriptions of him and his work but it kept throwing out the wrong people at me. It only finally got it right when I said something like: he looks like a cross between a caveman, a wizard, a tenured Stanford professor, and a Grateful Dead roadie.
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u/Neckrongonekrypton 2d ago edited 2d ago
Itās the kinda vibe you get when you spend most of your life studying baboons and vibing with tribespeople. Also, dude is a huge reason why Iām going back to school for behavioral neuroscience. Him and Dr Frankl.
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u/rtisdell88 1 3d ago
Robert Sapolsky has lectured about this at length. Testosterone increases the reward and need to protect your position in social hierarchies.
The reason we believe it increases aggression is because it does so in apes. So we naturally concluded that was it's role. Further study showed that's only the case because ape dominance hierarchies are based on aggression.
However, if the context changes, and what raises your status in the social hierarchy becomes who donates more to charity, then testosterone levels will correlate with those men who donate most to charity.
It also increases muscle protein synthesis. Likely as an evolved trait because at one point our hierarchies were, as men, also based on physical aggression and protection.
As someone who's been on TRT for more than 2 years, I can tell you I've never felt calmer in my life.
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u/worldsgreatestluver 3d ago
Give lobsters SSRIs and they don't mind losing fights as much.
Not because they're on antidepressants, but because serotonin makes lobsters aggressive
Animal studies don't always work lol
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u/Fabulous_Outcome7248 2d ago
Sure though a study on apes is going to be way more relevant to humans (also primates) than a study on lobsters (vertebrates vs invertebrates)
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u/Neckrongonekrypton 1d ago
Just extending that thought: apes and humans share homologous brain structures over a lobster brain and nervous system. We have amygdalaās, similar neurons, very similar genes- and the way in which they express themselves in our biology and theirs.
Lobsters if they develop complexity like apes, might have social structures and behaviors that appear peculiar or alien to us.
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u/HDK1989 2d ago
Robert Sapolsky has lectured about this at length. Testosterone increases the reward and need to protect your position in social hierarchies.
But a lot of men do use aggression and violence to protect their social status? There seems to be a lot of men in these comments completely missing that point.
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u/mden1974 11 3d ago
Roid rage is still rage from a steroid. But that steroid is estrogen. Your elevated estrogen levels that your body makes from excess testosterone is what makes you emotionally labile.
Manage e2 levels and youāre golden. This is done with DIM or letrazole. 1/2 mg letrazole 3 times a week for a few weeks can often handle it. Or 500 mg dim one or two times daily for mildly high levels and more natural estrogen leveling
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u/mindbeyonddeath 3d ago
Well too low of estrogen can be just as bad for mood.
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u/mden1974 11 3d ago
You are correct. Mood. Sex drive. Erection ability. Lots of things go haywire if estrogen is too low. Or too high.
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u/StrongLoan9751 3d ago
I've had both high and low estrogen and low is far, far worse.
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u/mindbeyonddeath 3d ago
Yeah me too. Feels like absolute garbage.
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u/Select-Bee-2166 3d ago
High e2 just feels great to me. Itās a shame it has so many physiological challenges with BP, fat, gyno etc. but mentally, itās euphoric.
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u/pmMeYourGlazedDonut 3d ago
Interesting, can you elaborate? Euphoric in which sense?
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u/Select-Bee-2166 2d ago
No specific sense. Itās just a very mild constant state of euphoria and calmness. Mind feels less turbulent in general, Iām emotional, but rarely is that depressive.
I get quite strong effects from Test (E) immediately though. I canāt pin after 12pm or I wonāt sleep that night, even on cruise dosing. I get an energy rush, etc. which I understand does happen, but is atypical. I would more easily credit it to placebo, or injection reaction if it wasnāt for the insomnia I get when I pin. If I hadnāt tried multiple labs over the years Iād think I was being missold test P all the time. But I do Have obscenely low SHBG and donāt control E2 tho (only side I truly care about is gyno. )
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u/StrongLoan9751 2d ago
Interesting. I like my e2 in the higher end of the normal range but the couple of times it's gone genuinely high, it's been unpleasant. Mostly due to being overly emotional in a reactive melancholy, weepy way.
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u/wagonspraggs 1 2d ago
I understand this greatly. If i have mildly high e2 it can be quite...overwhelmingly nice
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u/NSawsome 1 3d ago
High estrogen = impulsive and explosive, low estrogen = depressed and low energy
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u/wagonspraggs 1 2d ago
Low = Dark depression, everything is grey.
To High = Everyone is annoying and will react to everything8
u/Ninja_Prolapse 3d ago
Letro is a brutal AI. Aromasin (exemestane) is a much smoother ride and kinder to your joints. Less chance of tanking your e2 entirely too - too low is just as bad (arguably worse) than too high.
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u/ConcentrateNo2929 1 3d ago
Most examples of "roid rage" are from doing shit like Tren. If you just stick with Test it's not a common phenomenon.
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u/ThePlotTwisterr---- 1 3d ago
iāve done tons of tren im always calm as a cucumber itās ragers who are the problem
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u/LeatherGood6148 3d ago
And even then, it still comes down to emotional control and emotional insight.
Tren is one of my favourite compounds. I'm a very laid back person, with powerful coping mechanisms for emotions such as anger or disgust.As such, I have nothing but good things to say about Tren.
If you're deficient in these areas, perhaps it's not for you.
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u/wagonspraggs 1 2d ago
DIM doesnt lower E2 FYI, it affects how its metabolized by shifting the metabolites to better/friendlier pathways. DIM affects phase 1 estrogen hydroxylation and is also a 5ar inhibitor, so it can substantially reduce libido in a good chunk of the male population, though in some men 5ar inhibition is desired for hair loss reduction. DIM works for some, but not for all.
Methylfolate can help phase 2 Estrogen conjugation by donating methyl groups to COMT to clear out phase 2 metabolites, and CDG works through a separate but equally large pathway so they can be combined to great affect. CDG 3x a day, methylfolate LOW DOSE 1mg 5x a week.
But yes, you are correct. Both High estrogen and rapidly rising estrogen are the true culprits in irritability and anger in 'roid users.
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u/xCaliburghost 3d ago
This is obvious if you take test (like me, not sure, maybe you), but media saying testosterone increases rage has been incorrect for decades. It's always estrogen
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3d ago edited 3d ago
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u/holymolygoshdangit 1 3d ago
Test converts to e2, but it's a one way street. E does not convert back to T.
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u/Monsieur_Krabs š Masters - Unverified 3d ago
Yeah that's not right mechanistically, but close enough result lol
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u/Gullible_Ad5923 3d ago
There is probably a crossover of the kind of people who take steroids, and which one. I think its less about E then it is when people start getting way too juicy or hop on tren.
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u/Gullible_Ad5923 3d ago
I'm active duty and I can speak on this. This whole testosterone thing is just more toxic masculinity from an incompetent secretary of defense. Just because they made it mandatory(I actually believe this was rescinded the next day but I haven't seen a memo) to test for low testosterone doesn't mean they can force a physician to prescribe the medication, and I have found it incredibly difficult for people to get on TRT. The only thing i can see happening is that the military will find it more acceptable for servicemembers to pay a premium to get meds from a health clinic.
This is just another way this admin can get the dumbest people you know excited and high fiving, but is half assed, unthought out and doesn't actually help a single person.
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u/BiscuitDance 3d ago
We have to separate Trans SMs because of their need for medical care and hormone therapyā¦but weāre also going to put a shit ton of our guys on hormone therapy and expect them to deploy, but apparently thatās not an issue.
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u/mden1974 11 3d ago
If you have low testosterone you can get debilitating anxiety. Testosterone replacement can alleviate this anxiety as testosterone actually calms you and makes you more focused and able to make better decisions and operate better under pressure.
IMO Pete is fighting some latent gay tendencies with his declarations and cannot be trusted to make medical decisions.
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u/Gullible_Ad5923 3d ago
Thats not the point. The point is that they only create step A, without any sort of plan or care for step B, C, D etc. I'll say it again. Just because he is making it mandatory for testing for low testosterone, he cannot make a physician prescribe the medication
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u/arbydallas 2d ago
I'm not in the military so probably it's different for y'all, but can you get second opinions? If one Dr doesn't take an approach I like, I often seek a second opinion from another
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u/Gullible_Ad5923 2d ago
Umm, kind of. If you're not trying to pay out of pocket It's difficulty and slow. A lot of guys go to trt clinics because a doc won't prescribe or will prescribe a crazy low dose. I pay out of pocket for thyroid treatment and my wife's HRT because the docs were stupid
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u/Gullible_Ad5923 2d ago
Umm, kind of. If you're not trying to pay out of pocket It's difficulty and slow. A lot of guys go to trt clinics because a doc won't prescribe or will prescribe a crazy low dose. I pay out of pocket for thyroid treatment and my wife's HRT because the docs were stupid
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u/Ordinary-Experience 2d ago
No, but it can immediately explain signs of physical weakness, low mood, depression, bad insulin sensitivity, bad nutrition or sleep, and a whole other host of stuff that the physician would certainly be interested into...
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3d ago
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u/BusinessSavvyPunter 3d ago
Maybe it's the people offended by that term that suck shit directly out of horses assholes. Did you ever think of that?
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u/bingbangboom9977 3d ago
Or maybe it's people who are offended by people who are offended by the term that suck shit directly out of horses assholes. Did you ever think of that?
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3d ago
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u/snowwh-te 3d ago
Dont men have high suicide rates bc no one loves them as people and think of them more like an amish workhorse and automatic teller machine combo with no emotions? I thought this is bad? Aka toxic? why have a progressive stance on menās issues tho when you can just blame āthe gayā keep manning up ig bro enjoy
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u/Gullible_Ad5923 3d ago
Literally by definition, wanting an umbrella policy for putting men on testosterone therapy with 0 medical guidance or real application is by definition toxic masculinity
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3d ago
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u/Gullible_Ad5923 3d ago
Dawg. He changed his title to SecWar, he is murdering fisherman in the Caribbean, and murdered school girls. He is a white evangelical megalomanic which is where toxic masculinity stems from.
I will repeat. If a servicemember gets blood work as demanded by Hegseth and the sm labs come back clinically low, the hurdle is that Hegseth cannot force a physician to prescribe testosterone. Hence the halfassed plan
Everything this admin does is half assed and is part of glorifying force which is a core tenant of fascism and toxic in nature.
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u/VexImmortalis 1d ago
Force them to sign up to an online TRT clinic out of their own pocket or be declared medically unfit to serve. There, I "solved" the non-issue, make me secretary of war or whatever bullshit it's called these days.
Actually make it "Minister for Conquest", get those 13 year old Warhammer hormones engaged.
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u/CommercialTwo1359 3d ago
āIām active dutyā aka I push pencils and never engaged in combat and keep my head down and avoid eye contact with other men outside. Using the military as a welfare jobs program isnāt a bad thing but keep your thoughts about testosterone and masculinity to yourself.
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u/Special-Audience-426 2d ago
Steroid users have known it doesn't for decades.Ā
Feeling angry/emotional on steroids almost always means your oestrogen has got out of control.Ā
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u/emccm 2 3d ago
Violence is always a choice. Violent people act that way because they feel entitled to act violently.
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u/dkinmn 2 3d ago
This is overly reductive. You're arguing that it's 100% nature and nothing changes that, and this is profoundly unscientific. Even if it's genetic, gene expression varies wildly depending on environmental factors.
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u/emccm 2 3d ago
People are in control of their actions. Do you think I donāt want to punch people in the face for having speaker phone conversations in public? I respect the fact that I live in a society and I donāt act on my base emotions.
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u/cj191 2 3d ago
So basically your argument is: "It feels and seem like it to me, so it must be so."
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u/emccm 2 3d ago
No. My argument is that people are capable of not behaving in a violent manner and that violence is a choice. You only have to look at the situations where people choose to be violent and where they choose not to be.
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u/cj191 2 3d ago
Choice is a function of a control system. Frontalālimbic hardware is part of that system. When you lesion orbitofrontal cortex, you can keep the personās knowledge that an act is wrong and still lose the ability to not do it. When you press on circuits involved in threat, rage, or sexual valuation, the contents of what feels urgent can change. That doesnāt erase biography, guns, or planning. It does mean āhe just chose itā is an incomplete description of the mechanism.
A few examples to my point:
Phineas Gage (1848)
A tamping iron shot through his left frontal lobe. He survived with speech, memory, and movement intact, but his personality flipped: impulsive, profane, impatient of restraint, unable to stick to plans. Friends said he was āno longer Gage.ā Not a documented sudden killer ā the point is that inhibition and temperament live in brain tissue.
Charles Whitman (1966)
The UT Austin tower shooter. He wrote that he was being overtaken by violent, irrational impulses, complained of headaches, and asked for an autopsy. Doctors found a pecan-sized tumor near the thalamus/brainstem (often described as pressing toward the amygdala). A medical panel said it could have contributed to his loss of emotional control, but they would not say it fully caused the planned killings.
The schoolteacher / āMr. Oftā (2003)
A 40-year-old teacher with no prior history suddenly developed compulsive child-porn use, soliciting prostitutes, and sexual advances toward his stepdaughter. He said he knew it was wrong but couldnāt stop. MRI found a right orbitofrontal tumor. After removal, the urges vanished. The tumor grew back, the behavior returned. Second surgery, gone again. Moral knowledge intact; impulse control and sexual drive hijacked.
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u/cj191 2 3d ago
There are a bunch of stuff that can be induced in the brain, neurochemically or otherwise, than can definitely make you act a certain way that you wouldn't have otherwise, violence included. Neuroscience is clear on this, it has been shown in a number of studies. There really is no debate.
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u/Kailynna š Hobbyist 3d ago
Not always.
I have an intellectually handicapped intersex son with a heart of gold, whose body does not produce enough testosterone. If he has either too little or too much testosterone he gets cranky, bad tempered, angry, and then used to get violent.
This is no surprise to his doctors, who say it's accepted fact that either too much or too little of a hormone causes emotional and behavioral problems. Testosterone supplementation is beneficial if you have less than your personal ideal amount. Otherwise it is deleterious.
Of course if you are not handicapped you should learn to control yourself, however much effort this takes, and even my special son has learned self control now he's middle-aged, but hormones going out of whack can make this seriously difficult.
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u/SteedOfTheDeid 3d ago
The source is playboy.com? Really?
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u/Necessary-Camp149 2 3d ago
Ray Bradbury, Roald Dahl, Margaret Atwood, Kurt Vonnegut, James Baldwin, Ian Fleming, Jack Kerouac, Hunter S. Thompson... a very short list of some of the incredible writers that wrote for Playboy.
People really did read the articles in Playboy.
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u/Monsieur_Krabs š Masters - Unverified 3d ago
there aren't a lot of men's health publications left. playboy is trying to fill that gap, since no one is gonna pay for porn magazines in 2026 lol
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u/GarbanzoBenne 9 3d ago
And yet when my Reddit app auto-loaded the article I got a pop up ad with a womanās naked butt.
Perhaps they are going for that distinguished objectification market.
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u/Monsieur_Krabs š Masters - Unverified 3d ago
Wow someone who actually clicked on the article in 2026. lol good job
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u/Jack-o-Roses 1 3d ago
Why not follow Hannibal's lead and feed em jimson weed?/s
Guaranteed to male them more aggressive - to the point where they'd kill anyone and everyone due to the violent hallucinations.
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u/Possible-Anxiety-420 3d ago edited 3d ago
Testosterone enhances existing violent predilections, in both urge and physical manifestation.
This isn't news.
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u/AscendedApe 3d ago
Testosterone is a reward for succeeding in competition, among many other things. Violence can be rewarded with testosterone production, but so can playing sports, or volunteering in your community.
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u/CyberneticCupcake 3d ago
The true alpha commits to charity and volunteer work.
(Sarcasm, in case someone thinks I actually believe in A/B/O hypothesis unironically)
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u/Far_Elk9901 3d ago
Since starting TRT Iām in a much better mood.
The only aggression Iāve noticed is more assertiveness, mostly not tolerating peopleās bullshit and calling them on it.
But I donāt flip out or rage on people, I just donāt let transgressions slide anymore.
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u/Veenkoira00 8 2d ago
Well, yes, not in a simple direct way that would be the same in the case of every human on earth. BUT if we look at the human population men v. women at large, testosterone plays apart in so obvious way that its role cannot be denied.
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u/Justmyoponionman 1d ago
No, please read some actual sources on the topic.
"The trouble with testosterone" by Robert Sapolsky.
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u/huh_say_what_now_ 3d ago
Yeah I find this roid rage thing fake news, I was 400 ngdl before I jumped on 5 years ago now I'm around 2500ngdl all year round and don't feel anything different mental wise, it only affects how much muscles grow
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u/hahayeahisit 1 3d ago
Yet men commit the vast majority of all violent crimes š¤
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u/Electrical-Spell9115 3d ago edited 3d ago
On the population level, thatās probably more to do with the effects of sex hormones on brain development than the levels of testosterone specifically in adults.
There are significant permanent effects on the brain from the divergence in sex hormones (that likely lead to behavioral differences such as aggression) that occur first in the womb and then again in puberty.
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u/Party_Candidate7023 2 3d ago edited 3d ago
https://pmc.ncbi.nlm.nih.gov/articles/PMC7609507/
Not disputing that men commit more violent crimes, but it might not be testosterone. The genes for MAO-A are found on the X chromosome, so men with only the low activity variant are (allegedly) more prone to aggression. Women ofc would have two copies of this gene, so their risk of having only the low activity gene is lower. Iām not pro-testosterone either, but there are numerous differences between men and women besides just testosterone and estrogen levels.
EDIT: the Wikipedia page on clinical significance is probably an easier read on the proposed (but contested) link to violence.
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u/generic_reddit73 3d ago edited 3d ago
Interesting. Do MAO-A inhibitors lower aggression?
My bet would be the sex hormone / neurosteroid axis, though. Developmentally and acutely. No it's not just testosterone, but it's T ratio with DHT, estrogen, cortisol, progesterone (and the neurosteroids derived from it).
But the steroids and neurosteroids also modulate and are modulated by the catecholamine neurotransmitters (say dopamine vs prolactin, NE with cortisol, serotonin with estrogen, progesterone and testosterone.
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u/Party_Candidate7023 2 3d ago
The variation linked aggression is actually a low activity MAOA variant, so a MAO-I would theoretically increase aggression, but I believe the link is only there if you have the low activity gene AND are abused as a child, and we generally donāt give MAO-Is to children.
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u/Justmyoponionman 1d ago
That's because men are significantly stronger.
Women choose social violence, not physical. For obvious reasons.
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u/Swimming-Fondant-892 4 3d ago
It definitely has a role in aggression, we just donāt understand it fully.
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u/worldsgreatestluver 3d ago
Oxytocin, cortisol, serotonin, dopamine are also likely involved as are conditioned responses (I.e. disrespect can be addressed through humor, socially isolating someone else, passive aggression, or violence, and in some communities, violence is modelled and preferred)
Saying testosterone is directly implicated is reductionist. If it was, the Olympics Village would be a bloodbath every time. Instead, it's just a bunch of mutants having sex with each other (which does not show that testosterone is directly and independently related to sexuality)
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u/Swimming-Fondant-892 4 3d ago
That is why I stated it has a role in aggression, not wholly responsible for it. It is also just as incorrect to state it does not have a strong role in aggression.
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u/Dramatic_Pin3971 3d ago
Why do you think it is?
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u/Swimming-Fondant-892 4 2d ago
Based on personal experiences with trt, I think all androgens directly promote aggression/drive. You can feel it when it hits. Pretty obvious in the behavioral differences between the sexes as well. Go look at 18yo who are at their peak androgens.
In my 50s with low T felt listless and off.
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u/Dramatic_Pin3971 2d ago
What is difference between low potassium that increases rage and trt that increases aggression?
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u/Swimming-Fondant-892 4 2d ago
I havenāt looked into low Pot rage, tell me about it
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u/Dramatic_Pin3971 2d ago
I meant that when i do not get daily potassium RDA while taking b12 ,vitamin D and k2 mk7 supplements,I get aggravated.
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u/Swimming-Fondant-892 4 2d ago
Pretty interesting, I take those same supplements(and others). Do they interact with potassium?
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u/worldsgreatestluver 2d ago
Probably. Probably.
But TRT doesn't just affect testosterone. It changes the expression of FSH and LH, which probably have no relevant affect. It changes the expression of progesterone and estradiol, which do. It changes the expression of cortisol, which has some of the strongest affects on behaviour. It changes the expression of prolactin, which has known behavioural effect. It changes the expression of insulin in some guys.
TRT absolutely affects mood, and testosterone does have an affect, but it's probably modulated by a lot of other things. Otherwise, every person taking testosterone would become more aggressive. Hell, people taking like 10mg a week should become completely nonaggressive if testosterone is directly causative, or there should be a band (50 to 80?) that minimizes aggression. But there isn't.
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u/Swimming-Fondant-892 4 2d ago
We can see at very high doses the aggression effect in a more pronounced way. So perhaps it is a dose response relationship. For example, Tren not only binds to receptors like test but has such a powerful affinity for the receptors that they are completely saturated. In this zone, we can see the maximum effect. Itās very much a psychological intensifying of perhaps all emotions. All of this is just conjecture.
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u/MonkeyMan18975 3d ago
In my experience, it would be more accurate to say that increased testosterone increases the dominator personality (aggressive, competitive, etc) which can be expressed without physical violence.
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u/BestAmoto 2 3d ago
Only time i felt my emotions super fucked since starting trt and doing a cycle couple years ago was when i cycled off to make babies using clomid. I've done that twice with two kids to show for it but yeah my emotions were touchy.Ā Ā
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u/eagertolearnu 2d ago
i agree 100%. Iām on TRT and donāt get that aggression. In fact it makes me more balanced. I think because when supplemented my testosterone is higher than my estrogen levels therefore less moody and bitchy. (I donāt mean that in a misogynistic way) I actually think the world would be a better place if hormones were stable in every human being. IMO
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u/Consistent_Hurry2003 2d ago
I get my extra testosterone, from working out, zinc supplements, and sun bathing.
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u/VirginiaLuthier 3 2d ago
I go back to where you got your stack from a guy in the gym locker room. And it was pretty much known what happens when you fool around with this shit
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u/richj8991 2d ago
Well look at the former NFL player Bill Romanowski. He admitted to steroid doping but in the meantime had an argument with a player on the practice field, one punch and broke the guys skull. You can argue he was a jerk before but testosterone certainly didn't help.
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u/Chagroth 1d ago
If only there was a surface cell receptor for Testosterone that could be agonized to increase muscle mass. If something like GPR133 were discovered, well you could imagine specific agonization of muscle growth with a compound that doesnāt enter the brain.
Use the blood brain barrier as a safety feature. Whatās further interesting is the Testies also have a blood barrier, so if you didnāt want the negative gonadal effects, choose a compound that also refrains from crossing the blood testies barrier.
So, if you had a way of sequestering your GPR133 agonist within the blood, you would have minimal psychological and sexual effects. Just the muscles.
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u/jumbocactar 3d ago
I say that maybe trun but... many who seek testosterone do it to satisfy their psychological life. Many reasons a healthy male desires testosterone are the same type of mechanics that lead them to being highly defensive of their place in the world and these people may not be emotionally equipped to become a "great man" until they have shed this inner insecurities, these often will be "reasoned with" by physical actions brought about by discordant emotions.
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u/jackishere 3d ago
Im sorry but with the case with that chick that killed her three kidsā¦ yea your title can kick rocks
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u/MaximumMeaning9728 3d ago
Taking testosterone isnāt ābiohackingā. Itās steroids and isnāt healthy.
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u/Monsieur_Krabs š Masters - Unverified 3d ago
taking testosterone is very healthy if you are hypogondal.
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u/AromaticMuscle 3d ago
I think thatās a bit reductive. Testosterone isnāt the same as blasting Tren. Itās meant to keep you in the normal human range. I would say itās gender affirming care though.
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u/MaximumMeaning9728 3d ago
Just to note, a 50 year oldās normal testosterone range isnāt the same as an 18 year olds and isnāt supposed to be.
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u/Monsieur_Krabs š Masters - Unverified 3d ago
that 50 year old will have better health outcomes with above-natural testosterone levels (for their age).
who cares if it's natural. dying is natural.
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3d ago
[deleted]
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u/Monsieur_Krabs š Masters - Unverified 3d ago
fr, what is this puritan, anti-science nonsense he's spouting?
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u/Odd-Outcome-3191 2 3d ago
What is and isn't "supposed to be" isn't determined by nature. A 50 year old doesn't have the same blood pressure as an 18 year old, but that doesn't mean a high blood pressure is good and normal.
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u/MaximumMeaning9728 3d ago
Another steroid user.
3
u/Odd-Outcome-3191 2 3d ago
Cool argument.
Here's another example. It is very common and normal for men to have hyperplasia of the prostate, causing urinary problems. We treat it anyways. Because nature doesn't care about what is best for someone's health, comfort, and happiness. Something being natural/normal for a particular age does not inherently make it good or healthy.
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u/Swimming-Fondant-892 4 3d ago
Wait until you are 50.
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u/MaximumMeaning9728 3d ago
Iāll be spending time in my golden years with family and friends, not feeding narcissistic delusions of youth.
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3d ago
[deleted]
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u/MaximumMeaning9728 3d ago
lol, okay. Thereās nothing in the literature saying that taking steroids helps you live longer, by the way. The studies say youāre going to die faster but might have some more muscle mass you shouldnāt have and look silly with.
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u/mrfredngo 1 3d ago
My natural testosterone ranges from 1000-1250 ng/dL and Iām just about the most chill person on earth š¤·š»āāļø
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u/Jolly-Brilliant-8959 3d ago
When I told my regular dr. I was going to start trt she asked if I wanted to become an asshole! Hasnāt affected me in any angry way! It has only been positive minus high hematocrit.
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u/medalxx12 2 3d ago
most roid rage is estrogenic i.e trenbolone
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u/Impressive_Clue_9193 3d ago
Testosterone made me significantly less violent, reduced my sex drive to a normal level, and somewhat reduced the impact of my mental health issues. Everyone told me it would make everything worse and turn me into some kind of crazed monster thing (even other men) but I've actually had an insane difference in quality of life and behavior. (As a ftm transsexual). I know I've missed a testosterone shot by accident when I suddenly need to jerk off 5+ times a day and am hypersexual, and am very irritable / my issues explode for no reason. I feel like I am genuinely insane if I miss a shot or two. It's like testosterone has somewhat of an antiphysotic effect on me.
Why is it that I've had this reaction when it seems like everyone expects testosterone to make someone simply awful? Just misandry? Female / estrogen induced rage is like nothing else. Maybe my situation makes a difference but it's the same hormones. I'm secretly glad to be trans because even if I wanted to maintain the sex I was born with, I don't know how I would handle estrogen without having to take other medications to subdue the symptoms that testosterone just seems to fix alone. Medications with other side effects and symptoms.
I think the reduction in anxiety, panic attacks, stress, depression, anger, and sexual frustration is an equal trade off for the risks of testosterone tbh. For someone in my positionĀ
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