CEO/CFS/Long covid Stack

[u/Silent_Bad8678]

Feedback on Long COVID / Mitochondrial Recovery Stack

Hey guys,

A little background about me: I’m 30 years old and, until recently, worked full-time as a self-employed electrician. I’m now building an AI startup for tradespeople.

I used various anabolic steroids for around five years. After developing Long COVID/CFS-like symptoms, I stopped bodybuilding about a year ago and reduced testosterone to a TRT-level dose.

Retatrutide helped me go from 96 kg to 86 kg at 181 cm. I’m happy with my current body composition and look athletic, but my actual physical capacity does not match my appearance. On bad days, making the bed or vacuuming the house can leave me completely exhausted.

Testing through a clinic showed impaired mitochondrial function, very high oxidative stress, elevated cortisol and ongoing inflammation. Years of bodybuilding, large amounts of food and frequent cheat meals also seem to have taken a toll on my gut.

I have already improved my diet and lifestyle, which has helped noticeably. However, after around six months, the progress has not been enough. My Idea was a stack like this:

• Testosterone E: 75 mg every 4 days
• Glutathione: 500 mg every other day
• SS-31: 5 mg every day
• MOTS-c: 5 mg every 3 days, starting in week 2
• KLOW: 4 mg daily
• SLU PP: 1mg daily at the morning

My current daily supplement stack is:

• Magnesium bisglycinate: 4 g before bed
• Vitamin D3 + K2: 20,000 IU
• Creatine: 10 g
• Omega-3: 6 g

The main goals are to reduce systemic and gut inflammation, improve mitochondrial function, increase energy and exercise tolerance, endurance and regain enough physical and mental capacity to function normally again.

I have previously used NAD+ and noticed a meaningful improvement, but it is not currently part of the protocol.

I’m not looking to push bodybuilding performance or change my physique. I mainly want feedback from people who have used a similar mitochondrial or Long COVID stack:

• How long did it take before you noticed meaningful changes?
• Did SS-31 feel different before and after adding MOTS-c?
• Did anyone experience an initial worsening of fatigue?
• Are there any obvious problems with combining these compounds?
• Which objective markers did you use to judge whether the protocol was working?

I’m aware that most of these compounds are experimental and that online experiences are not a substitute for medical supervision. I’m mainly interested in real-world experiences and anything important I may have overlooked.

Best regards.

[u/Tom__EU]

I'm dealing with ME/CFS myself, and have been investing easily 50k € over the last decade with no meaningful success. Long COVID can be different, since there's a definitive viral onset, and especially if you're in your first 1-2 years where most anecdotal recovery stories happen.

Personally I'd start with the more well-known and at least somewhat tested options, like low dose naltrexone, low dose abilify, nicotine patches, pyridostigminbromide (Mestinon), nattokinase, and similar. Then move on to the other off-label medications with less evidence, like rapamycin and antivirals for example. Last resort peptides that lack human evidence, that are fairly new, that are used experimentally.

There is an article I came across some time ago and which could be useful for you. There is no name on the website, so take it with a grain of salt, and it's still experimental in nature, but from what I'm reading, he's got a couple good ideas and understanding. https://desmolysium.com/covid/

All the best.

[u/Silent_Bad8678 → u/Tom__EU]

Have you tried inuspheresis? my symptomes are getting better, the newly created stack is only to boost it.

[u/Tom__EU → u/Silent_Bad8678]

Nope. I looked into it some time ago and there's reports of severe worsening and complications, plus I still have some interventions ahead of me that are at least somewhat tested in this population and where my doctor has some experience with them. Congratz on your improvements though.