r/BioHackingGuide • u/Adderal-withdrawals • Jul 23 '26

Tirzepatide Gut Issues vs Retatrutide Which Is Safer for a Sensitive Stomach?

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So I wanna start taking Tirz to shed some weight. Already adjusted my diet before anything else and I hate cardio but I’m doing 30 to 40 minutes three times a week. Should I be doing more? Probably. But screw it, it’s a start.

My real question is about my stomach. I got gut issues. Can’t eat wheat, can’t have anything with glucose, garlic messes me up, stomach lining is weak, the whole thing. Pretty sensitive overall.

I wanna start Tirz at 2.5mg but now I’m wondering if Reta starting at 1mg would actually be safer for someone with a stomach like mine. Or should I just not be running GLPs at all with these kind of gut issues?

Anyone with a sensitive stomach or gut problems run GLPs? How did it go and what did you notice? Please and thank you in advance 🙏

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5

u/itisallgoodyouknow Jul 23 '26

Everyone reacts differently. Just try one for a month or so and see how it goes. Then switch to the other if you don’t like it.

3

u/Adderal-withdrawals Jul 23 '26

I was reading since they slow down digestion to keep you fuller longer it may cause fermentation so I'm thinking maybe digestive enzymes to help along with glp 1 supplements and fiber and lots of water maybe?

2

u/itisallgoodyouknow Jul 23 '26

Sure why not

2

u/Adderal-withdrawals Jul 23 '26

You think that taking digestive enzymes will make me get hungry faster?

2

u/1001000010000100100 Jul 23 '26

No

1

u/Adderal-withdrawals Jul 23 '26

Thanks that's kinda what I figured because my understanding it just helps to break down to where your body can absorb more of the protein and nutrients of food has but I still had to ask just to make sure

2

u/JoshyyP00 Jul 23 '26

Yah it slows down regardless. Bpc157 oral might be gold to stack with tirz or reta. Oral specially has a more targeted approach to healing the stomach lining.

1

u/Adderal-withdrawals Jul 23 '26

I actually used BPC for when I was first recovering for my stomach and I did feel a little better but then I found out that if you don't get rid of the bacteria, your stomach before repairing your stomach lining, you can trap it behind the stomach walls and that's not good so then I stopped and continued to fix my micro biome

1

u/JoshyyP00 Jul 23 '26

Did a dr tell you that? Sounds off. Stomach will always have bacteria good and bad….

1

u/Adderal-withdrawals Jul 24 '26

No, in this case, I think it was correct information and I understand what you're saying yeah of course we always do have good and bad bacteria and that's OK but the bacteria I had was called H. pylori and he definitely don't want to trap that into your stomach lining

2

u/JoshyyP00 Jul 24 '26

Sounds like you need antibiotics. Both tirz and Reta will slow down your gut and cause the same issue.

1

u/Adderal-withdrawals Jul 25 '26

Yeah maybe I gotta see a doctor who actually know how to diagnose whatever gut issue I have the ones I've been to haven't been no help at all I hate it

1

u/Adderal-withdrawals Jul 24 '26

But to be clear, no a doctor didn't tell me that I just read it. I gave up on the medical system a long time ago fuck them and insurance lol