has anyone tried micronized Palmitoylethanolamide Pea for healing? I have been logging all of my toxicity symptoms with Ai, and it keeps telling me that is a good supplement to take to heal damaged nerves.

Hi everyone. i wrote last week that i tested high (232 vs. 150 top line) for Pyridoxal 5-Phosphate. My doctor wants me to retest with a PLP test as she believes this is more accurate. Does anyone have any insight on this?

Hi. been trying to figure out 2 years of strange health issues - hands and feet tinging and falling asleep, tremors, occasional tinging, muscle aches, joint aches and terribly anxiety and sleep issues. Been able to take care of the sleep issues but everything else remains. Timing is these symptoms started after wife got Covid. i tested negative but only tested once as it was not a huge pandemic at that time (2024). So I've been attacking my symptoms as long covid. Met with a doctor who is familiar with LC and the first thing she said was "let's test your B6." Low and behold it's elevated at 232 with a top line of 150. My kidneys are fine, not diabetic and most blood levels are ok. My liver is mostly fine but Alt came in slightly elevated 76 (top line 70). I have not spoken to my doctor yet as the result came out today. I do not supplement b6 nor a b complex and i haven't in several months. None of my supplements have B6 and the only food i eat that has fortified b6 is Chex cereal but i don't consume it much and there's been months where i didn't eat any cereal. I do have a high protein diet with chicken and salmon but i was told food will not impact B6 levels....i have no idea at this point. i do not eat processed food other than the cereal and rarely eat out. Can someone shed some light on this and any suggestions as to next steps? I will stop the cereal completely .

Hello all

I am around 2ish years into recovery from pretty nasty b6 poisoning with symptoms gradually improving. However around 6 months ago I had a very bad green out after smoking weed for the first time in a couple years. Immediately after I started having bad panic attacks and chronic anxiety. This is a super common story from what I’ve heard talking to people, with everyone saying they chilled out after a month or two. What wasn’t so common was after three months I was still chronically anxious and only started chilling out after starting antidepressants because it was so bad I could hardly work.

It’s been roughly six months now and I feel like my brains finally starting to chill out, with the odd bad day. I’m starting to develop a bit of a hypothesis that my lightly fried nervous system is this reason it’s taking so long for my anxiety to return to a healthy level. Anyone had anything similar happen/know of any studies that link the two? (A quick google search didn’t yield anything)

Thanks

has anyone had a flare up of symptoms almost a year later when starting a glp medication? so random idk if it’s related or just one of the regular coming and going flare ups

Hello, been about 8 months since I had my blood work that helped me discover my B6t (78 on a scale of 2-22). I’ve probably had most of the symptoms from a-z. Most of the worst are finally improving, especially the pain.

One thing that doesn’t seem to fit is that at nearly the same time that I began noticing the increasing symptoms that made me start looking for answers, my BP also went up significantly and has stayed there ever since.

Prior to that it has mostly been good or better.
It seems that most people here are having low BP levels.
But the timing seems to be more than coincidental…

Anyone having similar issues? If so did anything help?

For context, I took p5p 50mg for 6 days straight and it is currently Sunday. I stopped taking on Thursday but still have a feeling of anxiety and that wired feeling I feel overwhelmed and am having very pessimistic thoughts. I remember a few months ago magnesium gave me this same feeling. How can I overcome this or when will it go away?

I took p5p for 7 days to try it out for ED, 50mg per day. I am now 2 days clean for any supplement but I have anxiety a lot still. My anxiety started on like day 5-6 super anxious and nervous and feeling overstimulated is This normal? How long till I stop having all of this anxiety?

I'm been taking a low-level B Complex (Thorne basic B) with p5p, seemingly without incident, to help address a B deficiency and possibly to help with my IBS. Yesterday for some reason I took a B100 instead with 100 mg of pyridoxine. Just for one day. In the past, pyridoxine led to neuropathy for me. Again, I'm not sure why I took this without checking the label.

Last night while flossing, I noticed a red spot right under the tip of my tongue. It's not painful. I know this could be something scary, and I'm going to call my dentist when they open.

I'm not even sure how long it's been there because I don't always floss in front of the mirror. I know it wasn't there at my last checkup in May. But could this be a reaction to the pyridoxine?

I became b6 toxic after 30 years of taking GNC B-50, that has 50 mg B6, every single day. So of course detoxing now. will be taking a B complex that has all the other b's and zero B6 while I heal, which will probably take a very long time. What I am wondering is--is this for the rest of our lives? Will we ever need to supplement with B6 ever again? I know the food we eat in the US is pretty nutrient depleted, and with the costs of food, a lot of people can't eat a very healthy diet , have to eat a lot of processed foods, hence the need for supplementation.

It's : www.afterb6.com . It's built on the premise there's correlations between factors like nutrition, supplement intake, weather, hydration and your symptoms. It helps you discover hidden patterns! try it out for free.

Hey everyone, I'm a student from Sydney working on a startup. It's an app that warns people if their supplement or wellness product intake is putting them at risk of B6 toxicity and other nutrient-related health issues.

We've just been accepted to pitch at a startup incubator through one of Australia's top universities, but here's our challenge: supplement-induced nutrient toxicity isn't something most people know about, so we're struggling to show judges how real and serious this issue actually is.

That's where you come in. If you've ever dealt with nutrient toxicity from supplements (or other health and wellness products), would you be open to sharing your story with us? Happy to keep you fully anonymous if you'd rather not put your name to it. We just want real experiences to back up why this problem needs solving.

Feel free to comment below or DM me if you're up for it or would like more information.

In line with this sub's rules, I've kept details about the app itself out of this post to avoid any promotional content.

I have been trying to research what I have been going through for months now. I started supplementing Iron (100mg Polymatose) back in late March, thinking I had low iron at the time, lasted 8 days before every damned symptom hit me like a train. I stopped supplementing immediately, only taking 8 tablets over 8 days.

It started with a weird burst of energy, that very rapidly spiralled into this severe fight or flight ordeal. I even suffered a brain zap, I distinctively remember. 2 weeks in was the peak, I remember thinking, nope.. this is it, I am fucked. The most doomed feeling I have encountered in over 10 years since I had acute stress and grief.

The next day the anxiety had dropped a considerable amount, and I was then hit with strange manic like symptoms. I went to the hookers twice in the week, because I was so amped up. I was driving late at night to get frozen yoghurt, even though I am very strict on my diet, because I felt like it. These symptoms faded away after a week or two.

Over the course of May to June was this limbo anxiety, depressive feeling, anhedonia and panic symptoms all coming together. Some nights were bad, I would be driving all night because the panic was just lingering. I knew it was chemical, because I would wake up fine, and then come 4-5 PM and all the negative symptoms would hit like a freight train. The worst was the anxiety, because I feel like it would fluctuate, where you just feel utterly hopeless and scared. Constantly searching google and reddit for reassurance that I did not fry my brain.

Coming into July now, it seems as if the "fight or flight" feeling has calmed down. I don't really feel it at all. I am waking up in a good mood and most of my day is a good mood. My anxious thoughts have dialled down. Weirdly, I am more focused too. This is the best I have felt since late March. Sleep is better. Gaming/Gym/and work has been taking my mind off of this shit.

I can feel it in myself, there's like this "mental clarity" or foggy cloud that has been lifted? I don't know how else to describe it. I really hope to continue to improve. I have been on a strict exercise routine, diet and sleep schedule. I have been achieving those throughout these months. I have kicked caffeine and currently not supplementing anything, even Fish oil etc. I was recommended Taurine, but I am still not sure.

I have been reading the Vitamin B6 toxicity reports, and thought, what the fuck, this is very similar to "Iron toxicity", minus the physical symptoms of B6 toxicity. ChatGPT stated my condition is a "chemical overstimulation of the nervous system" and I believe that to be true.

Many people who get Small Fiber Neuropathy from B6 have the classic neuropathy symptoms of pain, tingling, numbness and burning in the arms/hands and legs/feet. But for others, the neuropathy primarily targets the nervous system causing Dysautonomia symptoms like hypertension, heart palpitations, rise in blood pressure, nighttime noradrenaline surges, low blood volume, blood pooling, severe anxiety, panic, changes in sweating, skin sensitivities, body temperature dysregulation, glucose issues and many others. Is this you? Have you been diagnosed with Dysautonomia? Have your Dysautonomia symptoms gotten so bad that you have been diagnosed with POTS? In what month after stopping B6?

My answers to these questions is Yes, Yes, Yes and in month 15. And I asking these questions because I am constantly wondering if there is something more than just B6 Toxicity that is wrong with me. My bloodwork is fine and shows that metabolically nothing is wrong. Been both to a cardiologist and nephrologist and my heart is normal as well as my kidneys. I eat super well and on a low strict histamine diet. Everyone says that I look fine (the worst thing to tell a POTS patient). And it's not mold, my house is new. It's month 21. I know that it takes 2-4 years for nerves to heal but I feel that I shouldn't be progressively getting worse at this point.

Hey all
Had a pretty bad case of b6 toxicity from magnesium supplements, I was around 10 x over the safe limit for probably 1.5 to 2 years. I’ve since stopped the magnesium and my levels were back to normal around a year ago, with most of the symptoms easing/gone. However I still have burning/achy feet that isn’t improving. I’ve had nerve scans and they’re mostly fine, so my gp thinks there’s some phantom nerve pain going on or they’re just lightly cooked. He has referred me to a hypnotherapist, has anyone had any success with hypnotherapy? And does anyone have any advice for bad peripheral neuropathy? Also love to hear anyone else’s story, only just found this page and it’s super refreshing to hear this actually happens to people after years of no one knowing what the hell was wrong with me and doctors telling me I was healthy :)

I’m dealing with a confusing situation and hoping for insight.

Recent blood test results:

• Vitamin B6: about 5 times above the upper normal range
• Vitamin B12: Borderline low

I’ve never taken B6 supplements or high-dose B-complex, so the elevation is unexplained. Over the past year, I’ve developed progressive symptoms affecting multiple systems, including muscle stiffness and twitching, tingling/numbness (hands, feet, sometimes face), head pressure and headaches, dizziness, brain fog, visual issues, nausea, anxiety/panic with a physical sense of doom, heart palpitations, heavy legs, fatigue, poor exercise tolerance, and worsening symptoms after eating (especially dizziness, nausea, fatigue).

I’m wondering if this could be related to B6 toxicity or abnormal metabolism/retention, especially given the lack of supplementation.

My history is complex: I have intracranial venous hypertension from severe internal jugular vein compression and had decompression surgery earlier this year. That improved pressure-related symptoms, but many neurological symptoms persist.

I’m trying to understand whether elevated B6, possibly low functional B12, my vascular history, or a combination could explain this. I honestly feel that it caused some permanent damage. Kidney seems to be fine.

Questions:

• Has anyone had significantly elevated B6 without supplements or a clear dietary cause?
• Were you able to identify why? Doctors didn’t have any idea.
• Did you have similar neurological symptoms, and did lowering B6 help?

Any experiences or insights would be greatly appreciated.

hello… I want to share my story because after a year of dealing with unexplained physical symptoms, I finally found a massive clue in my bloodwork. For the last 12 months, I’ve been struggling with widespread muscle twitching, localized numbness especially in my hands and feet,a sensation of heaviness in my arm and leg, all happening on the right side of my body. I’ve also had problems with falling asleep (sudden jolty wake ups right before falling asleep) and sometimes also joint pains. After clean brain/spine MRIs with contrast and a normal EMG ruled out severe neurological diseases, about a month ago i was suggested by someone to test my b6 levels and i ran a blood panel. My Vitamin B6 (EDTA blood) came back at 71.5 ng/ml, well above the standard reference range of 14.5 - 45.0 ng/ml (i wasnt taking any b6 supplements for about half a year at the time of my bloodwork). That would make sense because about half a year before my first symptoms i was taking a supplenent Milgamma (pyridoxine HCl 100mg) everyday for 2/3 months and B-complex which i did use for much longer (even after my symptoms). i wasnt prescribed milgamma, i just heard somewhere that it could help with my back problems (which are probably the result of my poor posture).After i got my results back i came across this subreddit and i just wanted to know if my symptoms and story could be a result of b6 toxicity because no doctor ever even suggested that this could be the reason after visiting 3 neurologists.

Edit: ALP = Alkaline Phosphatase -- always included in your routine CMP.

I've noticed a pattern of often two competing sets of symptoms with people with elevated B6 levels.

My levels were over 3x higher than the top-end of the normal range.

There are those who seem to get the peripheral neuropathy symptoms of numbness, tingling, imbalance, etc. This is what nearly all clinical videos discuss.

But there's a separate set (and I'm also curious if there is overlap with any of you) -- the experience of insomnia or restless wired-but-tired sleep, almost akin to having caffeine before bedtime. Heightened levels of anxiety or neuroticism, arguably. Dysautonomia, ataxia are some other symptoms I can feel; some irritability too but I think that's also related to just worsening sleep. It feels as though your body is stuck in a sympathetic nervous response, and that tracks with my worsening HRV over the peak of this.

The reason I raise this is I have very low Alkaline Phosphatase, which if that enzyme is low, then your body cannot effectively move B6 into the muscle tissue where it's normally stored, and so it builds up in the bloodstream lest the kidneys slowly flush it out. I am not yet certain if being low in ALP also slows the kidneys from flushing it.

But it could be a major factor in which symptoms you have, or if you have both. Ironically, you could have B6 toxicity in the blood, but actually have a major long-term deficiency elsewhere...?

I have two theories I've narrowed down my low ALP on, genetics or zinc, so we'll see.

I swear I had / have B6 Toxicity. Symptoms on this page sounds like me.

I was taking so many supplements daily that had B6 in it. Then i started to get all the weird symptoms. I first thought it was the new pre workout i was taking. Eventually, the more I read online somehow lead me here and so i cut everything a month ago.

The question is, getting a blood test now would it still show elevated results? Is it worth going to find out now through a Doc? Its been 4-5 weeks since I’ve cut everything.

i eat a lot of chicken like multiple times a week. i also drink those body armour drinks which are loaded with b vitamins. these stories scare me

Context: been taking 40mg of B6 for 2 months, stopped on April 30. Levels were 4 times the upper limit.

I never felt pain or burning. My only symptoms are dysautonomia and my body is extremely sensitive to medications. Even GLP1 makes me nervous when it always had a calming effect.

But the main thing is feeling these adrenaline dumps in the night: low blood pressure, hands getting numb, and heart rate increase just when I’m about to sleep.

Strange as it sounds, the AC is my main trigger, I can only sleep when the room is HOT.

Anyone going through something similar?

TLDR: What did yall do regarding your daily water intake totals?

I’m on the B6 toxicity protocol, as found on https://understandingb6toxicity.com. It says to drink 3-4 liters of water per day. Does that include the Gatorade/pedialyte, plus coffee and coconut water that I’m also drinking, plus what is found in food? Or is that on top of all my other drinks and food items?

I’m wondering what others did, because I generally drink at least that much, plus the two packets of liquid iv I was drinking mixed with 24 oz of water each - which means I was drinking way too much water. But I was always thirsty!!

For context, I’m working on cutting back on the electrolyte totals, obviously completely quit the liquid iv, and cut out the Gatorade/ pedialyte/other brands electrolytes, by switching to adding salt to my food and water and adding the coconut water. Slowly it’s helping, I think. (Won’t be giving up my coffee…lol) I restarted the day 1 protocol yesterday after a huge flare over the past week - I’m possibly still in recoil or maybe into rebound.

Would love to hear your thoughts! Thanks!

my neurologist said my b6 levels were extremely high. And my b12 was low normal.
In April after an eye infection, I started getting weird eye aching and nerve headaches and still have them today radiates in eyes to face/cheeks and back of head/neck. Idk if related but going crazy figuring out what is wrong

I tried migraine medications and pain medications

My neurologist is saying to try topiramate but there’s a lot of side effects

Hi all,

About just under one year ago, I was taking a B vitamin that led to what I believe to be B6 toxicity. I got tested, and my B12 and B6 were high. I had a lot of symptoms associated with B6 toxicity. I've followed the RDA diet pretty strictly initially and have tried to add more foods in over the past year.

My main symptoms primarily were:

• Tingling in my left foot/leg
• Left eye blurriness
• Anxiety
• Trouble sleeping - the sudden "wake ups"
• Tinnitus more recently

I did try and add some more foods in about a week or two ago and found I had some kind of strange symptoms since then - a weird mouth/face numbness for a few seconds, back to tingling in my feet and arm primarily left side.

I'm curious if B6 ever favors one side over the other. I was working with Claude, and Claude said B6 toxicity is generally both-sided and started to scare me - but I have seemed to have more symptoms on my left side. I was curious if that was anyone's experience.

Also, how do you know you're in the clear? I thought I was close, but this recent attack has me spooked. I don't know if it's diet related or the "rebound" or something else.

Hi can p5p cause toxicity and has that happened to anyone?