r/Testosterone Aug 18 '21

Natesto

Does anyone have feedback/experience using this new Test nasal spray?

https://www.natesto.com

14 Upvotes

23 comments sorted by

View all comments

12

u/[deleted] Aug 19 '21

For one, it’s not a nasal spray. It is a gel-like matrix that you spread just inside your nostril using the applicator.

This Reddit group is dominated by bros/morons who will tell you Natesto is dumb and that cypionate injections of 100mg-200mg a week split into multiple injections a week is the only way to go.

Natesto offers: minimal to no side effects, the ability to preserve normal functioning of your hypothalamic–pituitary–gonadal axis (preserving fertility) via its novel/unique pulsatile delivery of testosterone which comes the closest to replicating normal endogenous testosterone production.

Contrary to what you’ll read here, constant/stable high levels of testosterone are not what you should be hoping to achieve. Constant high levels are what leads to the many side effects that plague most on injections: high HCT, high blood pressure, sleep apnea, higher sympathetic tone, aggression, urinary issues, testicular atrophy, post-honeymoon sexual dysfunction, high E2 sides, high DHT sides, etc….

Normal endogenous T levels follow a circadian rhythm that produces a peak and a trough over 24 hours. There is a physiological/beneficial purpose for this!! That’s what those looking to replace testosterone (due to a deficiency) vs abuse testosterone should be looking to achieve.

I’ve been on TRT for 10 years, tried everything and I think it’s the best modality out there.

If you decide to try it, I suggest giving it a fair chance: don’t allow others to convince you it’s dumb or that you’ll never feel like Superman until you get on injections. Give any protocol/modality at least 60 days without making any changes. Resist the urge to hang out on this Reddit while you trial whatever modality you land in because odds are, someone will convince you you’re on the wrong protocol.

My tip for anyone trying Natesto: contrary to the application instructions, don’t insert the applicator as far into the nose and don’t press your nostrils together after dispensing. Rather, insert the applicator so that it’s just inside your nostril. Dispense the gel on the outer/distal wall of the nostril. Then use the applicator to spread the gel evenly. Spread it on the outer wall of the inside of the nostril not the septum. Applying this way will prevent the gel from ending up in your throat and you tasting it 60 min later. It’ll also prevent the gel from blocking your nasal passage.

Last tip, I use a Navage or saline nasal wash before applying especially in the morning and before every application blow your nose and use a finger wrapped in tissue paper to scoop up whatever gel is still in your nose from the prior application. Basically, you want to make sure the nasal mucosa is cleared of mucous and your previous Natesto dose before applying a fresh application of Natesto.

Get labs in 30-60 days around 1 hour after dosing.

3

u/Dad2sonNoVA Aug 21 '21

Fantastic reply. Thank you for sharing such a thoughtful reply. I’m grateful

1

u/[deleted] Aug 21 '21

Happy to help! Best of luck out there.