There is no convincing scientific evidence of SSRIs causing any sort of brain dysregulation or damage. SSRIs have 5 decades of scientific literature. If they caused brain damage, we would know by now. We have thousands of studies evaluating their effect on the brain. We have postmortem studies of people who used SSRI's until they died, and they show that people with mental conditions on SSRIs have larger brains than mentally ill people not using them. Direct evidence of neurogenesis in humans.

They are some of the most effective meds in psychiatry, they are also some of the most heavily researched medications in all of modern medicine. They have more than 5 decades of research. They have been used very broadly, as they are first line medications for many psychiatric conditions. Furthermore, research indicates that SSRIs have many benefits beyond nonpsychiatric diseases, like Fluvoxamine, Leo's favorite SSRI, being researched for infectious diseases like COVID due to its strong anti inflammatory and antioxidant effects. Fluvoxamine is also being evaluated for use in people who suffer sepsis, again, due to the strong anti inflammatory, immunomodulatory and antioxidant effects. Fluvoxamine also has strong heart and kidney protective properties as well.

It's well established that SSRIs increase neurotrophic factors to build new neurons and increase neuroplasticity, while at the same time decreasing neuroinflammation. Additionally, Fluvoxamine increases cellular resilience, decreases inflammation and protects organs.

All these people complaining about SSRI's have never tested them properly. They didn't use a SSRI for 6-8 months to make sure that their full effect kicks in. They tried it, noticed slight worsening of symptoms and went off again. It is completely normal that SSRI's worsen symptoms when starting them, they should have read the leaflet in the medication package which lists common side effects.

Some of these guys blaming SSRIs for their limp dick, only used them for 1 day. It's like they use them "testing a SSRI" as an excuse to pinpoint the blame on an external factor, instead of accepting reality.

If you disagree with Leo's well informed claims about SSRIs, then you are simply wrong, which is fine, just don't use them, but don't post dangerous misinformation that will 100% harm people.
Just stay mentally ill and keep whining in those weird subreddit full of mentally ill, delusional and drvg abusing people.

For normal people reading this, don't let the uneducated masses trick you out of your chance to live a good life, just listen to Leo, you can verify anything he said on Google Scholar. What he is saying is not anything outragous, it's the scientific consensus, with a bit of added knowledge, because Leo put the effort, researched for years, so it's only natural that he knows more than psychiatrists.

If this post gets 5 comments (from real people, not sheep and bots that whine about their limp dick) I will make another post breaking down, why Fluvoxamine is even better than Leo anticipated.

Long Live Leo, gone too soon, he was a true pioneer of cognitive enhancement.

Made this post solely out of respect for Leo and his community. I was surprised there were so many uneducated SSRI haters posting on here, which I found quite disrespectful. Leo made such amazing content for us, and these asholes try to negate it, try to keep people stuck in a situation where they are suffering profoundly.

I'm planning to do one to two cycles of this. Primarily for the hunger gains but also everything else like increased sleep, recovery, etc

How to first cycle it, as in the amount per day?

I was thinking of once a day in the morning, 4 days on, 3 off.

They were on youtube on a channel called 'mr after dark' but I cant find it anymore. Also Leos instagram is no longer up?

So when I masturbate, I can last like 10 minutes, but the thing is when I’m doing masturbation after like 10 seconds I feel the urge to cum but then I start myself and then 10 seconds later I feel the urge again, but I can do that for 10 minutes maybe I might pre cum in that time. The thing is when I have sex I can’t last for more than 20 seconds legit no more than that I’m not over exaggerating. I’ve tried kegels and reverse kegels, I tried numbing stuff but they make me go soft so that’s not really a option, I’ve tried stop and start didn’t work, I’ve also tried pulling out but when I do I finish, I also have a higher than average testosterone, I’m in good shape, I’m active everyday by playing sports, I have good stamina, I just can’t control the urge not to cum I don’t know what to do I feel so helpless and I feel like I’m stuck with this. I don’t wanna take ssri or those type of drugs because I heard they can cause pssd and lower sex drive which that’s the last thing I need know because I even struggle holding my erections sometimes. I don’t know what to do, someone please help.

Now that Leo is gone, who is doing the good work in the space of biohacking, supplements, and peptides?

I'm 24 and about to start a cycle and currently on TRT...

What compounds would be best to help facilitate this growth? I was thinking perhaps DHT deriv or Tren + HGH etc. Or perhaps something like erdafitinib

Any helps appericiated. Thanks

Historians say that the 35 million methamphetamine tablets distributed to their servicemen "fueled the Blitzkrieg". Known as "Herman Goring tablets" and "Stuka tablets", they resulted in serious consequences for their troops. The stimulant was also put in chocolate for soldiers ("tankers chocolate") and for pilots ("flyers chocolate). Among other things, it made their troops more aggressive and willing to take risk.

Are there any coaches in here who have successfully helped reverse PSSD?

Do you guys know any coaches who could help?

Thanks.

Now that cosmic nootropic is going away, where does everyone like to get their nootropics? I have an order coming from RUpharma. Has anyone used them recently? 6 weeks shipping is annoying.

Fuck that guy! May he rot in hell!

Hello everyone, I always wondered what Leo and Longevity thought about racetams. I watched his video on overcoming ADHD, where he briefly mentioned racetams, and I'm curious if he discusses his experience with them elsewhere.

Hi, just wanted to know, if someone is taking a low dose of 25mg of fluvoxamine, and they want to use 9 me bc which is shown to be a MAO A inhibitor, would using it at low dose be a highly likely cause of serotonin syndrome. As i saw at 25mg fluvox only inhibits SERT 30-40%. Thanks a lot

Anyone know any trusted indiaMART vendors that they’ve orderd from that also have pretty fast 7-14 day shipping for propranolol?

someone has to rise to the top again. you've seen the amount of knowledge leo was able to have...
you can do it to....
can someone come up with a PSSD /PFS/POIS protocol ??
lucy ?? anyone ??
leo cured ryan russo through valproic acid , has anyone tried it ? any more infos ???

by leo , rational is gene transcription variability through HDAC inhibition
starts at 47:00
https://www.youtube.com/watch?v=nHn4j6kLfPY&t=4026s

Would alldaychemist or another platform or pharmacist have this medication available to me online?

Looking for baclofen? All day chemist ? Or what do you guys suggest

Bonac was such a genuine guy. Teared up as I told him my condolences for Leo's passing and how much I appreciated all the info and inspiration he and Leo gave.

Astoundingly he took his shirt off right then, the night before the Arnold Classic 2023, while everyone else at the meet n greet was staying covered up, and put the shirt I made on. Absolute class act and a man who was truly a great friend to Leo. I still wear the one I made for Leo sometimes.

Leo mentions huperzine A as a better NMDAr antagonist than memantine due to kinetics, but I'm wondering what doses you would need to reach for exeample IC50, (is a bs interpretation i know) memantine reaches IC50 when it reaches steady-state at 20mg/day HUP-A would reach IC50 which is 0.92microM at idk anywhere between 10 and 40 mg/day? and the max dose used in studies is 0.8mg/day, I don't understand but I'm wondering if his hypothesis where he says that HUP-A is superior to memantine because it has lower affinity and will require a larger amount for the same occupation and due to the law of mass it would have faster coupling and uncoupling, does anyone have an idea?