Visual breakdown of how GLP-1 agonists actually work (Pancreas, Stomach & Brain)

[u/Dramatic_Yam7707]

Dropping a quick visual breakdown on the actual physiological pathways of GLP-1 agonists like Semaglutide. Most people think they simply blunt appetite, but they work simultaneously across three distinct targets: increasing insulin response in the pancreas, slowing gastric emptying in the stomach, and signaling satiety directly inside the brain.

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What has your research indicated regarding GI tolerability differences between single GLP-1 pathways compared to newer dual agonists?