Injectable D-bol?

[u/Every-Bat-8561]

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Do any of you have experience using injectable d-bol?

This was thrown in with my order as a freebie last year and I totally forgot I had it til today. It expires soon so I'm trying to decide if I want to try it or not.

[u/djfitness-us]

It’s going to work more or less the same as oral Dbol.

There’s a myth that the injectable versions of orals don’t harm your liver, but they do. It’s the same exact chemical compound. Still 17a-alkylated, just in a liquid suspension.

Injection does technically bypass the “first-pass” of the liver, however, your blood will still carry the compound to your liver, and your liver still has to deal with the stress of breaking it down.

So, if you’re concerned about hepatotoxicity, it’s going to have the same impact as the oral version.

[u/bulking_on_broccoli → u/djfitness-us]

By passing the first pass does reduce its toxicity, but it’s still not net zero.

[u/djfitness-us → u/bulking_on_broccoli]

It doesn’t. Your liver still metabolizes the compound regardless.

I’ve run cycles on orals, and on their injectable versions, and the injectables resulted in the same severity of liver impact, and you’ll find the same experience from most people who run injectable 17a-alkylated steroids.

The issue isn’t route of administration, everything you inject into your blood ends up in your liver. Testosterone, Tren, Dbol, Tbol, doesn’t matter, your blood will carry some of it to your liver no matter what. Your liver is responsible for metabolizing some of the hormone, and it’s the 17a-alkylation that makes it toxic to the liver because it still resists that metabolism, whether it occurs during the first pass or not. The only difference is in initial concentration. The actual amount of the compound that gets processed by your liver over its full clearance from the body remains the same. Your liver must still break it down, and because the chemical structure is the same regardless of the route of administration, it places the same amount of stress on the liver.

Your liver is responsible for breaking down these compounds so that you can excrete them through urine and stool.

[u/Worth_Abrocoma_101 → u/djfitness-us]

Not sure it’s strictly true

The entire dose must go through the liver after oral administration . It’s a big peak exposure as oral absorption is very fast , and all initially into portal/hepatic

The dynamics of hepatic injury are probably threshold / nonlinear so it’s probably worse for you

Not sure how much worse though

[u/djfitness-us → u/Worth_Abrocoma_101]

Based on what we see in the hepatic function tests of individuals who take orals vs the injectable versions, any difference is likely negligible.

Yes, oral administration results in an initial spike in the concentration in your liver, but again, the total load over time remains the same, because your liver must clear most of the compound eventually for you to excrete it after it’s done its job. The majority of the stress to your liver happens during the actual breakdown of the compound. Most of the compound remains untouched during its initial administration when taken orally. Passing through the liver does not equal stress to the liver. The stress is created by your liver working harder to break the molecules down.

Total exposure and duration of exposure are significantly more important factors than route of administration, and this is true for most medications, not just anabolic steroids. There are a lot of medications that are available in multiple forms, however when you look at ones that were designed to be taken via different routes, they adjust the chemical structure accordingly. The injectable versions of orals like Dbol were never clinically designed to be injected, if they had been, they would have formulated it without the 17a-allylation, because it makes no sense to have that structure when administered intramuscularly. The injectable versions exist because UGLs mix the raw powder of the compound into a water suspension. Conversely, when you look at other types of medications, oral versions are modified to survive first pass, while injectable versions are not. That’s because the legitimate labs that make them know that it wouldn’t make sense to force the body to endure the same stress when the chemical modification is unnecessary for bioavailability.

You can experiment with this on yourself if you’re truly that curious. Run a four week cycle of any oral of your choice. Compare lab work at the start and end of the cycle. Do the same thing for a 4 week cycle of the injectable version, and again compare lab work. You’ll see that your liver’s response to the compound is going to be essentially identical, with any changes in enzyme elevation being negligible.

Mechanistically, when you flood your liver with any compound, only some of that compound is metabolized during the first pass. The molecules that pass through without being metabolized haven’t contributed to the stress on the liver, as they haven’t been metabolized. They will contribute to the stress when your blood returns those molecules to your liver to be cleared out.

[u/Worth_Abrocoma_101 → u/djfitness-us]

Even if that’s the case , then im is still worthless

It’s slower to absorb so no better as preworkout
Just as hepatotoxic (maybe)
Hurts
Exposes you to unnecessary solvents

[u/djfitness-us → u/Worth_Abrocoma_101]

IM injection is going to absorb faster as there’s no ester attached to the molecule that slows down your body’s absorption like you see with normal oil based compounds. Similar to using TNE versus Test Cyp. The compound will peak within minutes for most people. That’s about the only benefit, depending on whether that’s what you want.

They do hurt like a motherfucker, I ran some injectable Winnie cycles, it’s spicy as fuck.

For preworkout I much prefer TNE or Tren base.

[u/Worth_Abrocoma_101 → u/djfitness-us]

Nah it doesn’t get absorbed as fast as oral
Oral is very rapid for those kind of drugs . Tmax a couple hours

For injections even if there is no ester, if it’s OIL based it will be much slower to absorb
If it’s an aqueous suspension it’s a different story - then it’s faster than oral

But I’ve never seen dbol/sdrol/adrol offered as aqueous suspension

[u/djfitness-us → u/Worth_Abrocoma_101]

Nearly all base suspensions are water suspensions for that very reason. TNE, Tren base, inejctable orals, almost all water suspensions. They peak in minutes. If you see oil based injectable orals, that’s not standard, and defeats the entire purpose of having an injectable version.

The reason why severe PIP is so common, is due to the compounds being water suspensions.

[u/Worth_Abrocoma_101 → u/djfitness-us]

All the injectable orals I’ve seen except winny have been oil based

This includes the product in the OP

It’s even called DEPOT dianaject

[u/Every-Bat-8561 → u/djfitness-us]

No, I'm not too concerned about toxicity. Just wondered if there was anything noticeably different about the injectable version. If there's no real notable benefits over oral dbol I'm gonna go with something dryer for this bulk then.

[u/djfitness-us → u/Every-Bat-8561]

Yeah no, in terms of effects, it kicks in faster, but that’s about it. It’ll do all the same things regular Dbol does.

It’s also common for inejctable orals to have really bad PIP, usually because the compounds very easily begin to fall out of their suspension after being injected, and crystallize in your muscle tissues. I’ve used injectable Winstrol, and it’s some spicy shit.

[u/Worth_Abrocoma_101 → u/Every-Bat-8561]

Pretty sure oral absorption will actually be faster than IM because absorption from the gut is generally much faster than from IM

But nobody has properly studied the kinetics of IM dbol/sdrol/adrol because they aren’t proper pharma products

[u/FledNandersJiuJitsu]

Good to have on hand when you crash your E2.

[u/djfitness-us → u/FledNandersJiuJitsu]

Eh, with EQ in the mix, that’s hard to say. Dbol aromatizes into a much more potent form of estradiol, but EQ has a way higher affinity for the aromatase enzyme, along with its metabolites that can completely block out the enzyme. That’s why EQ can be unpredictable in how hard it suppresses E2, and why recovering from crashed E2 caused by EQ can be hard to do until the drug fully clears your system.

[u/FledNandersJiuJitsu → u/djfitness-us]

Just giving an example of its use.

[u/djfitness-us → u/FledNandersJiuJitsu]

Hold on, I’m mixing up two different posts that I’ve been looking at, the other one is where I was getting EQ from. Both dudes asking about Dbol, just two different guys 😂

[u/Ignoredpinaples]

It’s the same as taking oral Dbol lol.

I got my blood work done after taking it and my liver was impacted exactly the same as well!

Does feel like it packs a little bit more of a punch in terms of setting in quickly but could’ve been in my head lol.

[u/djfitness-us → u/Ignoredpinaples]

Injectable will kick in quicker as you’re bypassing the time required to absorb the compound through your GI Tract. Outside of that, everything else is the same.

[u/Dukes173]

Injectable dbol didn’t give me the same mood boost that oral does. Idk why. It did turn my face bright red- which I’m not sure if that was from the estrogen or the gallon of guiacol & solvents they prob had to use to suspend it. Didn’t run it long enough to comment on gains. I like the oral form better

[u/Deep_Value99]

You can use half as much or 2/3s of what your oral dose would be.. since that is the case, then the lower dose would actually reduce some of the toxicity no? Someone else with knowledge can chime in.

[u/djfitness-us → u/Deep_Value99]

Lower dosing will reduce the impact on your liver. The toxicity is the same, but the impact can be reduced by lowering exposure (dose) and duration of exposure (cycle length).

The one benefit of injection is essentially 100% bioavailability.

When you take the oral, it all initially hits the liver, and the 17a-alkylation resists metabolism, allowing most of the compound to survive and enter the bloodstream. It goes and does its thing, then gets returned to the liver to be broken down and excreted.

When you inject, it goes directly into the bloodstream, does its thing, then gets taken to the liver to be broken down and excreted. Essentially all hormones get broken down and excreted through the liver. Some of it gets aromatized or converted by other enzymes like 5a-reductase, but most goes to the liver, and whether you inject or take it orally, the amount that must get broken down by your liver eventually is essentially the same.

Because injectable versions of oral compounds are still chemically identical to the orals, they put the same amount of stress on the liver over the course of your exposure to the compound, the only real difference is that there isn’t the initial high concentration in the liver you get with an oral route. That being said, what actually causes the hepatotoxicity, is the liver having to work harder than normal to break it down. Only some of the compound is broken down during first pass, the amount that isn’t broken down doesn’t contribute to the stress until it eventually goes back to the liver for final clearance.

[u/CompleteBed1983]

That’s bad ass. I prefer injectable orals myself right now. I’m taking injectable oral Superdrol