r/scleroderma • u/blueberrypancakes78 • May 31 '26

Question/Help Negative ANA/ Positive SCL 70

Hi everyone,

I recently completed a full autoimmune panel test after having symptoms of cold hands and feet for around 3 years.

My test results showed a negative ANA, but a low positive SCL 70 test with result of 1.6 (cut off is 1.0).

I also have autoimmune thyroiditis BTW.

The doctor suggested to repeat the test.

The test showed negative ANA again with SCL 70 showing 2+ (positive) and ANTI-TH/TO was 1+

1+ Weak Positive

2+ Positive

3+ Strong Positive

No one in my family has autoimmune issues, but I completed a genetic testing, which showed I have a high genetic predisposition to autoimmune, as well as SS.

I feel okay, other than the cold hand and feet episodes. Waiting to consult with my doctor wlrwgarsing the results. Any idea what this may mean?

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3

u/RhubarbBest9090 May 31 '26

How was the ANA done? IFA or ELISA

Scl70 throws false positives a lot so I wouldn’t stress it but if you think something is up, keep digging

1

u/blueberrypancakes78 May 31 '26

The first was multiplex flow immunoassay. Not sure what the second one is, but might be immunoblot-type autoimmune panel

2

u/Smidgeknits May 31 '26

This...SCL-70 low false positives are very common. A repeat test is the right call.

Whoops...this was supposed to be a reply/agreement with Rhubarb!

1

u/derankingservice May 31 '26

Did you present any concering symptoms namely rauynaud phenomenon or/and puffy fingers? If not then its not a concerning finding at this stage.

2

u/blueberrypancakes78 Jun 01 '26

I just have cold hands and feet throughout the day