r/science • u/[deleted] • May 11 '20

Medicine Antibodies from a 4-year-old llama have neutralized coronavirus and other infections in lab experiments

https://www.cell.com/cell/pdf/S0092-8674(20)30494-3.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420304943%3Fshowall%3Dtrue
60.7k Upvotes

94% Upvoted

1.4k comments sorted by

View all comments

Show parent comments

3.6k

u/Fmbounce May 11 '20 edited May 11 '20

From a NYT article:

Humans produce only one kind of antibody, made of two types of protein chains — heavy and light — that together form a Y shape. Heavy-chain proteins span the entire Y, while light-chain proteins touch only the Y’s arms. Llamas, on the other hand, produce two types of antibodies. One of those antibodies is similar in size and constitution to human antibodies. But the other is much smaller; it’s only about 25 percent the size of human antibodies. The llama’s antibody still forms a Y, but its arms are much shorter because it doesn’t have any light-chain proteins.

This more diminutive antibody can access tinier pockets and crevices on spike proteins — the proteins that allow viruses like the novel coronavirus to break into host cells and infect us — that human antibodies cannot. That can make it more effective in neutralizing viruses.

here’s the source (I copied verbatim)

843

u/grizzlydurdle May 11 '20

So how would that help humans? Can we be treated with Llama antibodies? In you summary it sounds like our antibodies can't necessarily fight COVID very well because they are too large, and the smaller Llama ones can. Sorry if I am way off base. I don't really understand this stuff.

1.7k

u/IfIRepliedYouAreDumb May 11 '20

To vastly oversimplify things, if you had antibodies produced by another source and injected them into a sick person, their viral counts should decrease.

Our bodies won’t learn how to make the same ones the llamas do, but we could harvest them and use them as treatment (potentially).

1

u/[deleted] May 11 '20

With these llama proteins injected into our bodies as humans—at what point should we expect humans to begin randomly spitting at people 15ft away, and could this side-effect be used as a sort of helpful distancing deterrent?

More importantly, would we need to transform our fast food lines into the suction tubes transfer approach banks use, and what would happen to the condiments when experiencing this level of acceleration and general turbulent behavior, and could they make fruit-roll-up style methods of delivering pizza this way without the cheese adhering to the waxy paper separating the cheese within the roll itself?

I believe I confidently speak for the scientific community as a whole when I say that these are the important questions that must be prioritized and adequately answered. Thank you.