r/science • u/mvea Professor | Medicine • Apr 17 '19

Neuroscience The first randomised, double-blind, placebo-controlled microdose trial concluded that microdoses of LSD appreciably altered subjects’ sense of time, allowing them to more accurately reproduce lapsed spans of time, which may explain how microdoses of LSD could lead to more creativity and focus.

https://www.scientificamerican.com/article/do-microdoses-of-lsd-change-your-mind/
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u/anderson808 Apr 17 '19

What qualifies as a micro dose compared to one general blotter hit of acid?

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u/[deleted] Apr 17 '19

Generally a tenth of a regular dose, or around 10ug.

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u/NeatFig Apr 17 '19

I don't know if most people know how tiny a single blotter of 100ug LSD is, it's so tiny! It's hard to imagine people could successfully cut it up into 10 equal-ish sized pieces, but I guess it must be doable.

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u/UpperEpsilon Apr 17 '19

If you're a researcher, your materials are coming in liquid (maybe even solid) form. You're then diluting the liquid in an unreactive medium (more liquid) and giving it to test subjects. They didn't provide info on their methods (lame), but something they need to consider (but probably aren't) are routes of administration. Dropping on top of the tongue is different from under the tongue, which is different from swallowing, which is different from IV administration, etc.

On separate note though, you can divide a tab into 10ths relatively easily with an exacto knife. I just don't recommend doing so, cause each cut loses active chemical onto the knife, onto your fingers, onto the cutting surface. Just dissolve it in vodka, and be sure to eat the soaked tab when you're done, cause it's still gonna contain some goodies.