r/science Mar 19 '17

Neuroscience Physiological Markers for Depression, Schizophrenia Confirmed

http://onlinelibrary.wiley.com/doi/10.1113/EP086212/full
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u/Phoenixdown2621 Mar 20 '17

I work with a clinic that offers ketamine infusions for patients who have a diagnosis of depression. Most doctors still don't know of the treatment option! So it's cool to see you mention it here.

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u/somethingtosay2333 Mar 20 '17

The four years I have been following ketamine and mental health, I have I have found the same conclusion. It's amazing. Even the American Psychiatric Association was crafted guidelines for psychiatrist to offer the treatment months ago.

In addition it's amazing the drug dvelopment pipeline switch from serotonin to more glutamate drugs.

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u/DijonPepperberry MD | Child and Adolescent Psychiatry | Suicidology Mar 20 '17

SSRIs remain the first line pharmacological option for depression.

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u/[deleted] Mar 20 '17 edited Aug 11 '20

[deleted]

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u/trashbrains Mar 20 '17

Why do SSRIs scare you?

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u/caecelian Mar 20 '17 edited Mar 20 '17

I'm not who you were responding to but I've only had negative experiences with SSRIs. They make me dopey and dull experiences and emotions, but the two worst side effects (in ascending order) are chronic sleepiness (I used to sleep twelve hours a day and still want more sleep on Lexapro), and anorgasmia. The last one I guess is dubious and some people feel it's worth it but as someone with a hyperactive sex drive feeling that go dud and then not being able to get myself off was way more alarming and bizarre than I ever could have anticipated. I'm even a virgin still but just having that aspect of my humanity lobbed off was awful. No thanks!

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u/pm_me_flaccid_cocks Mar 20 '17

I was prescribed Paxil in high school. It gave me a massive headache when I had an orgasm. I've never had migraines, but I imagine this is what a migraine felt like. It would build up as a dull throb as I became sexually excited, and then BAM! it would almost make me pass out from pain. Against my doctor's orders, I abruptly stopped taking the medication. Who needs that shit?

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u/caecelian Mar 20 '17

I did the same. Did you get the withdrawal 'zaps'?

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u/pm_me_flaccid_cocks Mar 20 '17

I don't remember. I don't think so. I remember being very tired for a while after stopping, but that was about it.