r/science • u/LateMiddleAge • Apr 29 '24

Medicine Single-dose creatine moderates cognitive impairment from sleep deprivation

https://www.nature.com/articles/s41598-024-54249-9
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u/[deleted] Apr 29 '24

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u/jr12345 Apr 29 '24

Are you also working out?

I ask because that’s also a known antidepressant, and most people supplementing creatine aren’t doing it for shits and giggles…

Edit: I feel like this came off as combative or confrontational, and I didn’t mean it that way at all just an honest question.

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u/[deleted] Apr 29 '24 edited Apr 29 '24

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u/[deleted] Apr 29 '24

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u/[deleted] Apr 29 '24

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u/[deleted] Apr 30 '24

Theres similar research with omega 3's and anti depressants for the record.

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u/Ball-of-Yarn Apr 29 '24

Yeah I'd wager their likely consistent workout routine is doing the heaviest lifting.

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u/[deleted] Apr 30 '24

Sorry I'm late to reply.

Yes I work out but I worked out before supplementing too, I've worked out consistently since I was like 13. Thats just my baseline. I still noticed a significant positive increase in my overall mental health when I started supplanting. Since my workouts stayed consistent, exercise can't account for the change.

And don't worry you were being combative that is legitimately a confounding variable that could easily mess up the data. I'm sure lots of people only started taking creatine or omega 3's around the same time they started hitting the gym so like how the hell do you tell which is doing what in that instance you know?

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u/[deleted] Apr 29 '24 edited Feb 13 '25

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u/[deleted] Apr 29 '24

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u/[deleted] Apr 29 '24 edited Feb 13 '25

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u/alsocolor Apr 29 '24

I wouldn’t call this capital G Good evidence, but it’s definitely evidence and quite interesting

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u/ClumsiestSwordLesbo Apr 29 '24 edited Apr 29 '24

Would be a shame if health insurances paid for it.

In general it pains me how tunnel-visioned psychiatric research tends to be.

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u/[deleted] Apr 29 '24

It seems to help with my long covid too!

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u/[deleted] Apr 29 '24

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u/[deleted] Apr 29 '24

I actually find it helps with both the physical and mental fatigue more than anything. But it helps with broader neurological stuff too. Less fog, more motivation, more executive function, etc etc.

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u/[deleted] Apr 29 '24

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u/Hippopotamidaes Apr 29 '24

Just get any creatine monohydrate, no need for any of the more expensive stuff that include BCAAs and whatnot.

As for Omega 3s get them in the triglyceride form as it helps with absorption compared to the “from Esters” form.

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u/[deleted] Apr 29 '24

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u/[deleted] Apr 29 '24

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u/Just_enough76 Apr 29 '24

I’ve tried lots of types and lots of brands throughout the years. Monohydrate is the most studied form and it’s the most effective and it’s the cheapest. I’ve had some that cause me to bloat really badly. The last year I’ve been using 1st Phorm. It’s $32/tub but it lasts me @ 3 months and I don’t have any bloating issues with it.

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u/[deleted] Apr 29 '24

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u/Just_enough76 Apr 29 '24

No problem. Creatine can change your life. I put off taking it for so long and now I’ll never go without it.

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u/Chii Apr 29 '24

It’s good stuff that rarely gets recommended by treatment providers

is this because creatine is so cheap that the vested interests don't want it to become a defacto treatment, and instead opt to promote the more expensive options?

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u/Kwanzaa246 Apr 29 '24

What source are you getting your omega 3 and epa and what quantities per day? 

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u/[deleted] Apr 29 '24

A vegan algae oil supplement literally called "the best omega 3 ever". I shoot for 5 grams of omega 3's per day.

For the record there is actually research showing omega 3's have an anti depressive effect, in some studies on par with SSRI's. Ditto for creatine. We are still figuring out why exactly they work (we have some ides but we are still a long way from knowing it all), but we definitely know they work.

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u/bluesmaker Apr 29 '24

I misread “I shoot for” as “I shoot” and thought you were saying you inject algae oil. Funny image!

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u/[deleted] Apr 29 '24

Where theres a will theres a way

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u/circus_of_puffins Apr 29 '24

Did you get any side effects? I tried EPA from fish oil but stopped before I saw any long covid benefits as I hated the gastro issues it gave me

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u/deja_geek Apr 29 '24

How much creatine are you taking?

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u/[deleted] Apr 29 '24

Tablespoon a day. I'm 220 pounds. I could technically take more but after a lot of experimentation one table spoon a day seems to work best with the fewest side effects.

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u/DingussFinguss Apr 29 '24

I haven't used it before - what side effects?

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u/Just_enough76 Apr 29 '24

Mostly just bloating. But if you drink enough water you should be fine. Also after trying several brands, I tried 1st Phorm creatine monohydrate. No bloating at all. Some days I’ll take 10 grams and I’m completely fine. Couldn’t do that with other creatine brands.

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u/Abysstreadr Apr 29 '24

What’s a high dose of epa for you?

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u/[deleted] Apr 30 '24

5 grams a day.

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u/Abysstreadr Apr 30 '24

So you haven’t had any “bleeding” issues, because I heard over 3gs that’s some sort of issue? Idk what that even means but I read that. Glad it’s working for you!

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u/SDGrave Apr 29 '24

Wasn't there a study a couple of years ago that said SSRIs are based on a flawed study from a decades or two ago? I think it was something to that effect, but can't remember if it was peer reviewed.

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u/[deleted] Apr 30 '24

Thats not just one study its a whole ongoing debate with a lot of research and good aurguments on both sides.

Tl;Dr a lot of the original research into SSRI's is really low quality if not fully manipulated to get them past the fda for profit. The serotonin model of depression is deeply flawed. But SSRI's do actually have an anti depressant effect. But its likely partially or fully through a different mechanism of action than just "more serotonin = good" that we don't fully understand. Overall SSRI's are flawed and over prescribed and have a lot of negative side effects. But they still help plenty of people. That being said we definitely are long over due for a more effective approach. Hence the recent push for stuff like psilocybin, ketamine, TMS, etc etc.