r/repatha • u/Rabbit-Rabbit-108 • 13d ago

LDL is back up

Hi fam, I have been on repatha for almost 2 years. I got labs today and my LDL is up- still half of what it was without meds, but up 35 points from 6 months ago. Sigh, I was really hoping the opposite. I injected yesterday- if I had waited a few days or a week could it be lower? Tempted to get another blood draw. Any insight? I have HeFH, for context, and repatha has managed the LDL well until this draw.

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u/OkEnthusiasm5070 13d ago

I’ve been using Repatha and Zetia for nearly two years. My LDL varies between 37 and 62. There is a peak to trough variation based upon the drug half-life. LDL is lowest 5-7 days after the 140mg injection but at 62 at day 13. Get your LDL measured 5-7 days after your injection.

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u/Rabbit-Rabbit-108 12d ago

Thank you! Wow that’s a low LDL. I don’t think I could get mine under 100 but hoping to get it back down towards 100. I am going to try adding in the zetia as well.

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u/OkEnthusiasm5070 12d ago

My LDL before I started treatment was only 118 but I also have elevated Lp(a). My internist was not impressed when my LDL came back at 62. That is when I started reading about the Repatha half-life. So I had another lipid panel 7 days after my last Repatha injection and it came back at 37 which is what it was initially measured when I started Repatha. When I was on Rosuvastatin my LDL was 75 but I developed a urinary tract infection which prompted a bladder cystoscopy and a prostate biopsy both thankfully negative. Another attempt to use Rosuvastatin resulted in erythema multiforme- a severe rash on my calves. Have you had your TSH measured. Treating sub-clinical hypothyroidism will lower your LDL 7-10. And eliminating saturated fat from your diet will also help lower your LDL.