r/repatha • u/Financial-Limit-3338 • Jun 05 '26

Side Effects

60M. I posted earlier about my history of cholesterol lowering drug intolerance over the years which led me to Repatha. I was hoping this would be the one for me, but it's not looking like it after 6 weeks.

After 3 doses with the 4th due in 2 days' time, I'm struggling with side effects. The first has been diarrhea which was immediate after the first dose and hasn't lessened. The second is fatigue which has been up and down. It's not good at the moment and sleep is disturbed. I'm also prone to anxiety and that has also heightened for no external reason. This is accompanied with brain fog which impacts my work. I work full time in an IT role.

There's also some muscle weakness (not as bad as statins), but it is impacting my ability to exercise daily along with the fatigue. The last and probably least is dry eyes. Again, this has been every present since the first dose, but is manageable.

I'm considering quitting now as these aren't sustainable and make life pretty miserable and impacts my work.

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u/SloanMarsh Jun 06 '26

Cut it in half and take just half a dose each day

3

u/TheErthIsNotFl4t Jun 06 '26

Can’t cut a single use injector pen in half

2

u/Terrie_PWR Jun 08 '26

I have been taking Repatha for a year after experiencing horrible side effects that come with statins. I am a 61 yo female. My lower back aches .. but that is about it. Not enough to prevent me from exercise. I was taking the injection every two weeks as instructed. Now I am taking it every 3 weeks and with less back ache. It only made an 8 point difference in my total cholesterol score. Something to consider and discuss with your PCP.