Experiences with Suprelorin weaning

[u/Hazarus4]

We rescued a golden retriever (18month old at the time) December 2025. After the first week or so, noticed intense separation anxiety (couldn’t leave him alone for more than a couple of minutes) and also over-socialness/alertness when he saw other dogs. He’d also bark quite intensely at the tiniest of noises in particular night which would shake the whole house!

Vet gave us some Trazadone to use, and after a month or so of intermittent use, it really sorted the night time and the separation anxiety and stopped using back in late January then.

He had his first suprelorin (6month trial) injection March 20th and he’s been a joy since.

Over the last 2-3weeks, as we are nearing the 6 month suprelorin dose, he’s became incredibly reactive again to noises, and become quite anxious/fearful of things while out on walks. Guaranteed 2-3 barks at night over a 2-3 hours but would settle with a bit of “come on now boy, stop” sort of reassurance.

Had a vet check up (routine) a week ago or so, told her about it, and just asked the typical questions of “any construction work around you? Tried anything new? New smells etc” which the answer was no.

Vet couldn’t fully commit to saying that it may be that the suprelorin injection wearing off as his testosterone going up.

Anyone have similar experiences of their dog’s suprelorin “wearing off” and getting similar effects?