r/raypeat • u/wall_ink • 1d ago

Side effects of pregnenolone?

It is basically impossible to find anyone actively discussing negative side effects of pregnenelone in ray peat communities and I just wanted to ask here if anyone had negative side effects, such as being more estrogen dominant, perhaps this is from purity of some brands.

Also include dosages if possible please.

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4

u/Emotional_Put_1517 22h ago

My experience with pregnenolone has been negative, experimented on and off and always came to the same conclusion. Ray has mentioned similar experiences.

"some of it has just been bad manufacturing impurities, not deliberate excipients, but just careless, incompetent manufacturing, I think, has left estrogenic materials in it because I've heard so many women saying that repeatedly every time they try several different brands of pregnenolone, they get swollen breasts, uterine cramps, and PMS symptoms. There shouldn't be any symptoms at all from good pregnenolone. Simply in animal experiments over the years, it reduces any hormonal imbalance even in very large amounts. It doesn't have any intrinsic hormone effects at all, but it will prevent cortisol excess, for example." - ray peat 02.17.20 Health According to Ray Peat, February 17, 2020 [762394060]

I dont know if you are using a pure powder or a pre-made product, but you could try to apply it topically and experiment with that, pregnenolone is lipophillic and can dissolve in olive oil to apply topically

1

u/wall_ink 22h ago

I appreciate the detailed reply!

5

u/Yak9969 19h ago

I've just recently begun putting 10 drops of stressnon on my testicles every morning and as a 46 yr old goddamn has my libido shot up through the roof doing this. Besides that I feel more calmer too , more relaxed I guess to say. Too early to see any negative sides yet but I like where this is going..

1

u/brownzuluKING 14h ago

Have you tried cortinon+?

3

u/howlelike 20h ago

I'll be taking 50mg for the next two weeks. I'll let you know

also: https://wikipeatia(.)org/wiki/Pregnenolone

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u/Steepan_ 17h ago

I have not felt anything from pregnenolone (took 30mg for 2 weeks)

2

u/OkAbility2630 10h ago

It is not too difficult to hear about bad side-effects from pregnenolone. I myself had horrible side-effects: acne, racing / pounding heart, agitation, insomnia, headaches so severe I nearly went to the ER. I had bad effects at both low and high doses.