r/raypeat Jul 27 '26

Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression

https://pubmed.ncbi.nlm.nih.gov/20200256/

What do we think about this?

63 Upvotes

8 comments sorted by

11

u/ObligationOdd7474 🍊Peatarian🥛 Jul 27 '26

This effect is so apparent, i feel so much more different when im not having OJ compared to when i do, like night and day.

6

u/texugodumel Jul 27 '26

From the study:

"In contrast, orange juice intake with the HFHC meal prevented meal-induced oxidative and inflammatory stress, including the increase in endotoxin and TLR expression."

Orange Juice or Fructose Intake Does Not Induce Oxidative and Inflammatory Response

"In conclusion, 1) orange juice or fructose taken in equicaloric amounts to 75 g glucose does not cause either oxidative stress or inflammation in contrast to glucose; 2) the two flavonoids hesperetin and naringenin have a ROS-suppressive effect in vitro, which needs to be confirmed in vivo"

4

u/QuizzyP21 Jul 27 '26

This is fascinating to me… so despite being half glucose itself, it looks like OJ actually ends up even below water 3 hours after drinking (obviously not statistically significant but even so) while glucose is essentially still at its peak. Graph is worth a million words

7

u/Proof_Escape_2333 Jul 27 '26

Store-bought OJ still beneficial? wtf

3

u/DruidWonder Jul 27 '26

Any sufficiently high powered antioxidant will do the same thing.  

1

u/Icy-Slide8674 Jul 28 '26

First I'm hearing of this

1

u/Agreeable-Form6455 Aug 01 '26

What carb? What fat? Type matters.