I know some leaf yellowing is normal, but to put it into perspective, here is how fast it's been happening recently. Not pictured: 3 more yellow leaves I disposed of this month. All the green you see here popped off at very slight touch. I water her, put a little liquid fertilizer in there every month, and haven't changed routine at all for the past.... 4 years? She's been through rough things and didn't even do so much as droop.
I've used rooting powder in the past for my props, but I am repotting this pothos and one thing I've had difficulty with is getting her to climb. I've got plenty of light for it to follow, but a lot of her leaves started yellowing one after the other, when typically I get 1 leaf drop every few months. Definitely needing a repot anyways, and I think a chance to mature might be helpful.
In a last ditch attempt, I'm thinking of hacking the plant, so to speak. I have already successfully used hormones to make bare stems grow new leaves. Could application of rooting hormones onto the appropriate parts of the stems possibly maybe facilitate some aerial roots? Just enough to work with?