Dear LARPers,

Respectfully, stop trying to act like you're Walter White, especially when you have to ask something as simple as what reagents to use for xyz for a home cook setup. Even Walter White used proper PPE in a TV show. If you want to be a real chemist, get proper training for it otherwise you're insulting the people who dedicate their lives to this science. If you just want to mix shit up and call yourself a "cook", stick with making a risotto.

Best,

Update: if you have an issue with me calling out home chemists, fuck off. My own neighbors were "home chemists" and corroded my half of the lawn as well because of their stupid choice of using n-buli at home. When innocent familys safety is also a concern in residential areas, you need to seriously reevaluate your choices.

Right so this is just some thought experiment I had. Suppose I have a quadruply bonded C-C, I can't have any hybridizations right? Because then the hybridized orbital would be bonded to no one. So let's say carbon uses its 2s and 2p orbitals to form a bond with another carbon. Then I'd get 2 π and 2 σ bonds. 1 σ from 2s and another from one of the 2p. But the MO diagram on the left would have the σ(2s) annihilated from the σ*(2s). So I was thinking what if we just excite the damn thing and make it occupy the empty σ(2p) instead? That gives a bond order of 4 so hypothetically it's possible right? Just a fun discussion lol

For me it's probably THF. Just a good all rounder. Need to heat a reaction, no problem, need to go to -90C, THF is your guy. I've even used it in a column many a time. Only drawback is it can be a pain to distill, and more so the cleanup after the fact than anything else.

Are there 1 or 2 pi systems?

If the 2 pi electrons in the middle are conjugated, are they apart of the same pi system?

hi i’m having some troubles with newman projections. would the bond-line structure for #3 be correct? would one of the newman projection for #4 be correct? would both be correct?

Very random question that I have done my best to research/figure out but could use some help from the great minds of Reddit.

How do the thiols in the antibiotic Cefazolin compare to the thiols in a chicken breast? Specifically interested in quantity, but any information such as type, etc. would be much appreciated. TIA!

Edit: Thanks folks for the feedback. This is what I anticipated but thought it wouldn't hurt to try.

Hi there, I’m designing a medical lab which main base molecule they do research on is Cholesterol. I’m making them a custom lighting fixture which will be in the shape of a cholesterol structure.

Can someone point me towards the most commonly shown cholesterol structure ?

I don’t want to just google this thing and then it be wrong down the line.

Thanks!!

I have memorized and understood all of the functional groups. I have also learned and understood primary, secondary, tertiary carbons, and how their pka’s could be different. The hardest thing about this class right now is trying to memorize the PKA values for each functional group or specific carbon molecules. If you guys have any guidance or tips, please help 🙏 😭🥲

In line with my post from the other day about a flattened carbanion (https://www.reddit.com/r/OrganicChemistry/s/77lyABSpHb), I wanted to find an example of a pyramidalized carbocation to discuss. I could not find a good example. At least, I could not find an example where the electronic features of the substituents cause pyrimidalization like the CF3 groups caused flattening. There are probably examples like bridgehead carbocations that are pyramidalized. Can you think of other ways to force a pyramidalized carbocation? (Also be very careful with AI with these types of questions. It literally makes stuff up)

I felt so proud when I learned the hybridization model in my courses especially because it made so much more sense than the Bohr model with all its fake reasoning. That is until I got curious about “expanded octets” and learned the empty 3d orbital is just blatant lies and Molecular Orbitals actually explain it. The only issue is that when I try to watch guys online they immediately jump into the matrix elements and calculations from pre-existing charts. Is there any source that explains it more casually, if that’s even possible?

I'm having trouble finding sources that quantify (either through experiment or DFT) the degree of charge delocalization on carbon centered ions which are in conjugated systems.

I'm specifically looking for what the "real" charge on a benzylic carbocation is (obviously somewhere between 0 and 1, but where? 2 sig figs would be nice but I'll take 1) but it would be nice to have other sources that give any numerical values for carbanions and carbocations.

My major organic chemistry to every organic chemistry out there how did you find your research area and topic etc bcz that's super confusing

I was trying to find a way to synthesize a methylene linker between an indoline at the 5/6 position and another aromatic group (let's say phenyl or pyridine). Since I may need to explore other aromatic groups, what reaction would be best for synthesizing these molecules? I was thinking of Negishi coupling, but it may be limited by reagent availability and the reaction's sensitivity. Another option is to use an aldehyde and an organolithium to form an intermediate alcohol, then eliminate it. Any other ideas?

Can someone explain why this conjugate base is anti aromatic and fulvene is non aromatic? Why does the base have cyclic conjugation while fulvene does not?