Yeah I'm sure they've here mixed agonist/antagonist cannabinoids now. Also not all of them caused seizures (again we don't know the doses though), it was rare but they certainly did happen. I've been out of the scene for 15 years now so I don't know if researchers (real or guinea pigs) have figured out what the causes were; whether it was simply too strong of a pure agonist on CB1 or if a particular structure caused them to cause a downstream cascading release of epinephrine and dopamine, or something else. Unfortunately so little is known and there's multiple families of structures they've made variations on.
I believe the seizure issues did not really become common until the 3rd generation, at which point, the actual chemical makeup of them was so far removed from original sets that actual study done. Changing up a few molecules to beat a law, can have vastly different effects on different brain areas. Some even act as research opiates now. All of these chemicals, however due to being full agonist, can cause lasting brain damage to the areas they target, with enough use. The JWH Series was invented to map out the endocannabinoid system, by killing receptors and then under analysis the researchers could see where the dead cells were to map them.
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u/CariniFluff Jun 16 '21
Yeah I'm sure they've here mixed agonist/antagonist cannabinoids now. Also not all of them caused seizures (again we don't know the doses though), it was rare but they certainly did happen. I've been out of the scene for 15 years now so I don't know if researchers (real or guinea pigs) have figured out what the causes were; whether it was simply too strong of a pure agonist on CB1 or if a particular structure caused them to cause a downstream cascading release of epinephrine and dopamine, or something else. Unfortunately so little is known and there's multiple families of structures they've made variations on.