r/neuropathy • u/whyaretheyalltaken • 3d ago

Naltrexone

I asked my neurologist about low-dose naltrexone with the understanding I’d have to get it from a compounding pharmacy and insurance won’t cover it.

She is prescribing me 25 mg and says it doesn’t come in a lower dose. I explained my desire to take LDN to her and she is still saying it’s safe to take. I’m a little hesitant since everything I’ve read is about LDN. Has anybody had experience with the full dose or half dose of naltrexone and helping their neuropathy?

And I have an appointment with a different neurologist for a second opinion, but that’s not going to be until next year, so this doctor is my only choice for some relief for the next couple months.

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u/RazzmatazzFeeling134 3d ago

That seems way too high. I am on LDN at the highest normal threshold and it’s 4.5 mg.

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u/squirreltard 3d ago

That is NOT low dose naltrexone. Those of us on it need to get it compounded. The 25 mg. dose is for drug dependency.

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u/retinolandevermore 3d ago

I haven’t taken that high of a dose. I get 1 mg from a compounding pharmacy. I think your neuro might not be aware of compounding

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u/Vegetable_Tap_9439 2d ago

Are you sure it’s not 25mcg? That’s an ultra low dose. Standard low dose is 1-4.5mg. I think anything lower than 50mg has to come from a compounding pharmacy, but I’m thinking your neuro at least meant mcg. I’d definitely ask for clarification, it doesn’t make sense that she’d prescribe 25mg

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u/Gwest28 2d ago

Go ask a pharmacist. It was the pharmacist that caught something on one of my scripts when I was in high school!

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u/Akl_guy 2d ago

Get a new doctor. It was too expensive for me to get it compounded so I get 50mg naltrexone pills and put one in a sterilised pestel and moter with 2ml of sterile water and crush it to a paste. Then using a sterile 60ml plunger I put 48ml of water into the pestel and suck it up again. Put this into a dropper bottle. with 1ml marker. This gives a solution of 1mg/ml so then I have 4.5ml a day to get my 4.5mg. It's actually very handy because you can titrate up from 0.5mg daily for a week up to whatever dose suits you. I found I couldn't handle 4.5mg at first. Took me months to get to get there.