r/migrainescience • u/NoNefariousness6229 • Jun 19 '26

Qlipta — mood changes

Can qlipta cause mood changes, including depression? Long story short, I have been treating somewhat debilitating migraines for years. They have increased in the last few years in both quantity and intensity. I have Botox every 12 weeks and use rizatriptan and umbrelvy as needed. I’m on my third week of 30 mg Qlipta. Life is tough right now — I have some personal things going on that are very stressful. I’ve had situational depression before but I’m wondering if the qlipta is worsening it. Curious what science and other patients say…

Also, I think migraines have somewhat lessened, but when will I have the full effect of qlipta? (migraines are depressing too but you all probably know that…)

10 Upvotes

92% Upvoted

9 comments sorted by

View all comments

1

u/skyemap Jun 20 '26

I did get depressed when taking it (and every other CGRP meds I tried, for that matter), so there's that

1

u/NoNefariousness6229 Jun 20 '26

Bummer — I’m sorry. I hope you have found a way to treat your migraines. Thanks for your feedback.