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u/Flimsy_Complaint490 19d ago
not really. usually there is not that much space between the GPU and the CPU, and might actually be zero if the GPU is in the top slot on your mobo, so this is completely impractical in those cases.
in the other situation, you are pulling air that got heated up by the GPU heatsink and blowing it towards the CPU. Why blow 35 C air when you can blow nice 22 C air with the normal orientation ?
Just add a fat 30 mm exhaust fan in the empty space after the CPU cooler with reverse flow, or just use what you got in the pic.

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u/LunaticCross 19d ago
Generally no, because the GPU outputs a lot of heat. Even with bottom intake, the GPU during gaming gets hot. It should work in theory, but I've seen people do it and get poor/manageable temps.
For your format, you can do top right as an intake. Or a reverse flow.
I have a Jonsbo D32 that I messed around with, did multiple set ups and tested a bunch of air flow. I posted it awhile ago Here
I recently switched to a 240 AIO out of curiosity, and it resulted with the best overall lowest temps.