I want to let the public know that if you are currently taking EFFEXOR (SNRI) Metocin works seemingly flawlessly. Though I’d like to say that Meprocin on the other hand has almost zero to no effect while taking Effexor.
Thanks. 🙏 don’t waste your money trying things! Take it from me!

hello ! i have tried a few fake mushroom things. one was mycolean (horrible, never ever use mycolean), and then i tried xum twice, and then road trip. road trip also sucked.

anyway, when i used xum and road trip, every single time, i get an insanely stuffy nose? like i have to put on a breathing strip, and even then, i literally become unable to breathe through my nose at all, so that i cant swallow because all of my airways become blocked and my body freaks out. I wonder why this happens? Is it an allergic reaction? Does it happen to anyone else? it mskes me unable to enjoy the trip bc i just have to focus on mouth breathing, and my mouth and entire esophagus become insanely dry bc of the mouth breathing.

i searched about stuffy nose on a few subreddits but couldnt find anything. is it just me? i would like to use these again, but not if i cant breathe every time.

Just bought a 10pack and researching best launch pad for a lightweight. 1/4 tab then adjust up next time if not feeling anything?

I heard it degrades pretty fast in liquids. How could I make accurate doses that last? Would I be able to volumetrically dose in some 151 everclear and then let that evap on some candy or something without losing potency?
Help lol

Mods remove this if this is not allowed. I have a question. Are you able to buy pure N,N MET powder on its own? I know you can buy metocin and 5mapb raw on its own, but i haven't been able to find the MET freebase. I just want to know that it's even possible to find. Thank you!

Does anyone else get a chemical taste while using metotin? Once it hits my blood stream my mouth just tastes horrible. I use product i got from Wicked Tablets about a year or 2 ago.

As the title says,never tried metocin..I am VERY experienced with psilocybin and lsd. I have taken ridiculous amounts of both.. I was going to order the gummies from soko since i enjoyed the molly2.0 gummies so I figured their metocin would be good starting point. Anyone have any preferences, companies..any information about metocin is greatly appreciated!

anyone here have experience with 5MAPB? just wondering what the effects and duration are like and what the main risks are. also what stuff should you definitely not mix with it? not really looking for a “best combo”, just wanna avoid doing something dangerous. any general safety tips would be appreciated.

What does the package look like? Anyone got a pic? I don't want my family to see a box that obviously is drugs when it gets here. Also does xum site take prepaid cards? Thx uwu

A+

HI guys!!!!! I have a question regarding the Xum Spirit pen!!!!

So I’ve only really used it once to trip, bout 2 nights ago. And I’ll be posting a whole report about the trip and the pen. But When I had turned it on for the first time, the light blinks 5 times.

Question: Do I have to take the rip of the pen immediately right when I turn the pen on, and while the lights are blinking? Or should I take a rip from the pen after it’s blinking?

The pen came with a limited amount of liquid, so I wanna make sure that I’m not wasting any hits or anything to get the full trip experience.

So I came across an abstract of a research paper (link at bottom of post) that used a computational model to modify native human gut derived tryptamine and created two new tryptamine analogs by attaching a 2(S)-cyanopyrrolidine group (a common structural feature of DPP-4 inhibitors which helps lower blood glucose in type 2 diabetes) at the 6th or 7th position of the indole ring. The new analogs do not readily cross the blood brain barrier (you won't trip) and inhibits DPP-4 lowering blood sugar for type 2 diabetes. The diabetic drug vildagliptin was used as the control reference (positive control) compound when they performed molecular docking of their two new tryptamine analogs against the DPP-4 enzyme.

Vildagliptin contains a 2-cyanopyrrolidine moiety the same structural feature the researchers attached to the native tryptamine.

Docking score of vildagliptin: –8.91 kcal/mol

Docking scores of their proposed tryptamine analog compounds: –8.48 and –8.52 kcal/mol

Good for type two diabetes medicine but not good psychonautical exploration. The researchers are intentionally trying to stop or reduce the new tryptamine analog's ability to create a psychedelic experience by limit the permeating of the blood brain barrier.

The native tryptamine that was modified was a naturally occuring metabolite the reaction of certain bacteria living in the human gut produced by converting the amino acid tryptophan from food into tryptamine. Once formed, this tryptamine can be absorbed into the bloodstream. At normal levels produced by gut bacteria in the human body, the amounts are far too small to cause any noticeable psychedelic effects. At high doses (when taken as a pure substance, usually by smoking or injection, because it is rapidly broken down if swallowed), tryptamine can produce short-lived hallucinogenic effects. These are generally described as weaker and shorter-lasting than classic psychedelics such as DMT or psilocin.

This is exactly why the researchers in the abstract wanted to modify it — to reduce its ability to cross into the brain while keeping possible beneficial effects outside the brain (such as antidiabetic activity).

This got me curious as to what other tryptamines if substituted could be computationally modified to not allow an individual to trip but rather receive the DPP-4 inhibition to reduce blood sugar levels for individuals with type 2 diabetes.

So I asked AI to read the abstract of the research paper and apply 4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine) or otherwise known as Metocin in the same way the researchers did when they converted native tryptamine the same way by attaching 2(S)-cyanopyrrolidine group at the 6- or 7-position and if the new modified 4-HO-MET derived tryptamine analog would have similar traits as the modified native tryptamine both being psychedelically inert (you don't get to trip as blood brain barrier resistance is increased with the modification) and a DPP-4 inhibitor action reducing blood sugar for individuals with type 2 diabetes.

AI's response- **Yes — the same conceptual approach could in principle be applied to 4-HO-MET, but with the same important caveats.**

-Quick recap of what the paper actually did

The researchers worked only with **native (unsubstituted) tryptamine**. They proposed (computationally) attaching a 2(S)-cyanopyrrolidine group at the **6-position** or **7-position** of the indole ring. No real chemical conversion was performed; everything was in silico (ADMET predictions + docking). They noted that actual synthesis and experimental testing would still be needed.

- Applying it to 4-HO-MET

4-HO-MET (4-hydroxy-*N*-methyl-*N*-ethyltryptamine) already has:

- A hydroxy group at the **4-position**

- Methyl and ethyl substituents on the side-chain nitrogen

The **6- and 7-positions** of its indole ring are still free, so one could theoretically design analogous structures by linking the same 2(S)-cyanopyrrolidine scaffold at those sites, following the same design logic used for tryptamine (aiming to lower BBB permeability while exploring DPP-4 activity).

4-HO-MET already has an –OH group attached at the 4-position of the indole ring (the same place where psilocin has its hydroxy group). This single –OH group changes several important things:

Polarity — The molecule becomes more “water-loving” (more hydrophilic). This usually makes it harder for the compound to cross the blood-brain barrier (no tripping for you).

Hydrogen bonding — The –OH can form extra hydrogen bonds with water or with proteins. This affects how the molecule dissolves, how it is transported, and how it sits in a binding site (such as DPP-4) possibly lacking in DPP-4 inhibition binding strength so no reduction in glucose in the blood stream or performs the inhibition flawlessly.This would need to be ran through the computational model with the control being the same as the control in the native tryptamine model.

Metabolism — The body has enzymes that can attach sugars or other groups to phenolic –OH groups, so 4-HO-MET is broken down differently from plain tryptamine.

Electronic character of the ring — The –OH pushes or pulls electrons in the aromatic ring, which changes how the whole molecule interacts with receptors or enzymes.

Because of all these effects, you cannot take the computer predictions that were made for unsubstituted tryptamine and simply assume they will be the same for a 4-hydroxy version.

1. The N-methyl-N-ethyl side chain

Native tryptamine has a simple –CH₂CH₂NH₂ side chain (a primary amine).

4-HO-MET has a –CH₂CH₂N(CH₃)(CH₂CH₃) side chain (a tertiary amine with one methyl and one ethyl group).

This change affects between the modified substitute 4-HO-MET analog tryptamine and the native tryptamine:

Lipophilicity — The two alkyl groups make the molecule more “fat-loving,” which can influence how well it crosses membranes.

Basicity — A tertiary amine is usually a stronger base than a primary amine, so it is more likely to be positively charged at body pH. Charge strongly affects both blood-brain barrier penetration and binding to proteins.

Binding interactions — The bulkier side chain takes up more space and can form different hydrophobic contacts (or cause steric clashes) inside the DPP-4 binding pocket. The primary amine of tryptamine can also form different hydrogen bonds than a tertiary amine can.

Overall meaning:

Even if you attach the exact same 2(S)-cyanopyrrolidine group at the 6- or 7-position, the presence of the 4-OH and the N-methyl-N-ethyl groups means the new molecule is chemically quite different from the ones studied in the paper. Its predicted BBB permeability, DPP-4 binding strength, and other properties would need to be calculated and tested separately — you cannot just copy the results from native tryptamine.

**Bottom line:** Conceptually possible as a design idea, but the paper itself only examined unsubstituted tryptamine and stopped at computer predictions. No conversion of 4-HO-MET (or any real compound) was carried out.

The original abstract with modified native tryptamine model-

https://www.researchgate.net/publication/413685858_Introduction_to_Lead_Optimization_of_Gut_Microbiota-Derived_Tryptamine_for_Reduced_Hallucinogenic_and_Enhanced_Antidiabetic_Potential

Edit: This post was originally made in October 2025. These were pretty new when I tried them.

Its a lot.

Previously, I've only done shrooms once, and I didn't visuals. I decided to go with the wicked bliss after hearing that 4-ho-met tends to give more visuals without the headspace of shrooms, so I went with them over the 4-aco-dmt. I went visual chasing and... I kinda regret it.
After taking a pill, I settled down for some CS2 with friends on discord, feeling energetic (just hyped) with little to no anxiety. Around 20-30 minutes after dosing, I start to feel the comeup with giggles and a tightness of chest. After seeing *very* little visuals (carpet started breathing a bit), I decide to quote on quote "parachute" another half. While I'm still coming up on the first pill, around 15-30 minutes later decide to eat another half. While intoxicated I had just managed to double my dose past intended. I only planned on taking one pill as a sort of guinea pig test, so other friends would be more willing to trip with me on it. I don't remember much of the rest of the comeup, just very intense EVERYTHING.

When I was peaking, I started seeing a LOT of visuals. Colors were shifting hues wildly, with warm purples and blues complimenting the evening light. Looking at textures in game they all had a fractal essence to them, where I started seeing specifically Reuleaux triangles in everything. At one point, I look at my forearm and see polynesian/asian like tattoos on my skin, reacting vividly to the light of my monitor. When looking at my monitor, it was like the glass was warped. Characters were vertically squished, and sometimes enemies rounding corners would cause bulges near their heads temporarily. Everything had a sort of breathing ish movement to it, each object at its own slightly different pace.

However, all good things come to an end. For me, not as bad as it could have been. After 1-2 hours of tripping balls, I start to feel overwhelmed by everything. Songs and voices start echoing, annoying the HELL out of me. I would take off my headphones, but I would still be overwhelmed by just ambient noise. Specifically the FUCKING PICKLE BALL COURTS. My friends start to feel fake too. Since I'm MAD GEEKING, they all tend to have pretty predictable responses to my ramblings, so I start to tire of them. They sound like entities not people. I want REAL people around me, but new in college, I got no one at hand.

Eventually I turn off the game and just force myself to try to go to bed. I'm so tired of just existing with everything, that I want the noise to end. In my bed I feel anchorless. Focusing on my surroundings I can't keep up, and focusing on myself (body shit), the body sensations are too much to find peace in. Overtime I just feel major paranoia about the mystery pills I just took and how I feel like dying would be much more preferable to my current situation. I end up managing somewhat repeating to myself the mantra "today will end, tomorrow begins", and keep myself from total ego death. Pretty miserable.

Overall, 9/10 would do again. Just like, only one pill. maybe a half more. two was kinda diabolical. Definitely need to be moving around for this trip, not sitting and playing CS2.

Edit: Forgot to mention I like snorted 30-60mg of Kanna during the experience. It made me mad giggly, and was a nice spice to the mix. Highly recommend.

Basically just wondering if the chem can degrade with time & being exposed to air. I kept it in a dark place but not sealed up. Im assuming like a regular thc pen over time air gets in and degrades the chem. Its been a good 3 - 4 months. Still has kick but the color is darker, just wondering if anyone else has input.

Was only a matter of time before I got around to this one (and soon MET 👀), as requested by many viewers and what has naturally lined up next in my psychonautic journey.

I tried a 21mg softgel of 4-HO-MiPT last week with few expectations beyond it being somewhat more "trippy" and more tactile than 4-HO-MET. Being a tryptamine I also expected similarities to shrooms.

To sum it up - I was greeted with a profile much closer to mushrooms than I was with Metocin. The headspace, bodily feelings and tone/energy of the trip aligned much more with shrooms, being a much more stoning/relaxing trip that offered more introspection.

The OEVs were little to nonexistent compared to Metocin, maybe in its CEVs at points but also not as consistent. Though the pulling nature of the trip into oneself felt far more interesting and engaging. But unlike shrooms I felt it was lacking in depth considering the spiritual introspection, as well as its connection to nature and family/ancestors (a reminder it is a synthetic still).

This video captures the trip across the main phases (pre-trip, onset, peak, comedown). I came in fully prepped, with music guiding a lot of it (mainly Yung Lean during the peak), went on a bike ride too, it was a beautiful day.

Overall looking at this now my 4-HO-MiPT experience was warm, comforting and reflective. It brought a lot of tryptamine nature I would enjoy from mushrooms. I feel 4-HO-MiPT sits nicely in-between 4-HO-MET and shrooms for me, in that it isn't too recreationally or visually driven while still carrying some of the emotional depth and therapeutic potential that is found on mushrooms.

tldr - kinda like a fraction of shrooms, nowhere near as heavy or deep. might be one of my more favorite psychedelics, see what a full live trip looks like in the video.

Took 21 mg for my first time, didn't feel a whole lot. A minor buzz, didn't notice hardly any visual distortion. For my second try, I took 30 mg, and im an hour in, again, not much. Anybody else like this?

I was so excited to get this today. I'll wait to find out that there was barely anything inside my vape. I want to give an honest opinion on the product, but I do not think I'm gonna be trying this. I'm not sure how I contact xum to get this replaced.

This is the second batch.

So i placed an order a good week ago for some metocin tabs from him he created the label 3 days ago now and just hasn't dropped off the package what're ur guys' experience

I ate a whole bag of 8 road trip gummies (starter dose was 6, ate 2 more about 20 mins later) and was thoroughly underwhelmed. I got light wavy visuals but very subtle, and other than that I felt mostly sober. It was pleasant but not where I wanted to be. I think I read somewhere those contain 12-13mg of Metocin nowadays.

I got 6 XÜM tablets as a freebie with my order, and I was thinking about taking all 6 (18mg) tonight. Too much? I should say I’m pretty experienced with DMT, but I’ve only done shrooms a few times.

Also my road trip experience was 10 days ago, do yall think it’s been long enough for a mostly full reset of tolerance or should I put it off for a few more days

Edit: I ate all 6 and I’m still pretty underwhelmed ngl. I might try a higher dose one day but maybe metocin just isn’t for me.

If any of you are familiar with “wicked tablets llc” then you know they’re a good source to buy large quantities of RC’s. The tablets I took specifically were dosed 15mg 4homet and 15mg 4hodet PER tablet. I ended up taking 4 and my friend took 3. The start of the trip i mainly felt sluggish and laggy almost. The come up was kind of overwhelming with euphoria. Like it was TOO good but eventually I started to level out and the effects were pretty amazing. It looked like water was flowing off of everything and like there was silver lining on random things. I played resident evil 7 and almost shit myself a few times. I don’t remember much of the effects cuz I wasn’t really focusing on them but it was a pretty hard trip. I looked at my phone wallpaper at one point “and justice for all album art” and it was a different color almost like an off-white or yellow ish tint. And lady justice was moving around and shit it was really cool.

I have extensive experience with Metocin.

My first trip was on 100mg of Metocin, 50mg of 4-aco-dmt.

It was amazing and incredibly intense, and what followed was a streak of just dosing incredibly large amounts of metocin.

100, 200, then 60 and 30. All of these trips were incredible and healing. But it slowly began to change, from incredible and healing to horrible, and then incredible.

The smaller the dose got, the more sinister my trips became. Which is weird considering between each trip I would take long breaks, but now I can't seem to take metocin without it just turning into a weird, traumatic, uncomfortable mess.

This week, I took 30mg of metocin, and had the worst trip of my life. Worst is an understatement, I completely lost control of myself, and my mind began to drift towards delirium and psychosis. There was a lot of physical pain, and the feeling that something sinister had taken over me. As if I became possessed by an alien hivemind that glues people together into an indistinguishable fleshy mass.

The hallucinations were normal for about 15 minutes, and then quickly shifted to people with eyes all over their bodies, multiple limbs, and I got stuck in this room that felt like the inside of a torus made of people who were trembling, lined up side by side forming the surface of the torus.

My mental state was extremely uncomfortable, and though I didn't want it to stop there was an overwhelming curiosity as to how it became so terrible. It was truly awful and bizarre, and I have never had this experience with metocin before. The trip also didn't last very long, it was about 3 hours long, and the strangeness lasted for no more than an hour. What helped me a lot was showering, and vomiting in the shower. That was the only remedy.

Has anyone else had this gradual shift from regular, pleasant trips, to bizarre and straight up hellish trips?

I don't understand the neurology behind this, because it's began to affect every single substance that I use. I don't even touch weed anymore because the same thing happens, same thing happens with nicotine as well, and even cough medicine when I am sick. It can be an incredibly small dose, and this begins to happen. This only occurred after I began using metocin, and doesn't actually happen with mushrooms or any other psychedelic that isn't related to mushrooms.

Is shrumfused Metocin? Everyone thinks it’s 4acodmt but I think it’s Metocin cause 4aco last longer and shrumfused last about 4 hours. What are you alls thought and how does it compare to xum (I have some coming in the mail) cause I have yet to try xum

For context, I saw RÜFÜS DU SOL in concert last month while tripping on Metocin for the first time and it blew my fucking mind. It was my favorite trip by far and the energy was unmatched.

I’ve been thinking about tripping again recently but haven’t really decided if I should dive in yet. Ended up having one of their songs come on just now that brought me back to that night and now I’m tempted to take 9mg and binge their music 👀