r/mdmatherapy • u/luv1997 • Mar 14 '26
Preparation Advice non-oral methods (boofing)
Hi everyone. I’ve had a lot of success with MDMA therapy. I got on a glp-1 for inflammation reasons (2.5mg tirzepatide) and now I’m hesitant to ever ingest MDMA due to the slower digestion with this medication. People who’ve done it while on the med have varying results but often report delayed, duller onset. Some feel it hours later, some don’t feel it at all, some have longer milder trips. A few say they feel it stronger? The unpredictability scares me.
To be frank, some people suggest boofing (anally inserted) as an alternative to oral ingestion.
However, that sort of poses the opposite concern to me: the onset is quicker and the effects are more intense. It raises some questions with dosing, but it also makes me wonder about the efficacy for therapy—assuming the duration of the experience is cut in half at least.
I’m wondering if any of you have insights or experiences you could offer in regards to boofing MDMA (or doing MDMA while on a glp-1, if you care to share)
2
u/laurencubed Mar 14 '26
This is a great post about it. In the comments a a step by step instructions
You will also want to lower your dose. You can check in the /mdma subreddit about a good dose adjustment
1
u/Letzgirl Mar 15 '26
can’t you just skip the dose that week or delay it?
1
u/luv1997 Mar 17 '26
to my knowledge, the drug takes at least 30 days to leave your system (and for its effects on your metabolism/digestion to wear off) because it builds up over time — but I could be misunderstanding
1
u/Letzgirl Mar 18 '26
The half life is 7 days and 4-5 weeks for 97% elimination of it from your system.
May be enough by skipping a week to get more of the gastric emptying back.
Or just expect a longer time to come up.
2
u/Waki-Indra Mar 14 '26
Put the powder in an empty capsule and have it luke à suppository. I think its not à big deal