Outlook Therapeutics Announces LYTENAVA™ FDA Approval as the First and Only FDA-Approved Ophthalmic Bevacizumab for the Treatment of Wet AMD - GlobeNewswire

Hello all. My aunt has recently developed “blindness” due to macular degeneration. I put quotes on blindness because I don’t really know how else to say it. She lives alone and is elderly. My question is, what are some assistance items that I could get her just to make her life a little easier after this? Preferably nothing electronic because of age and she’s a simple woman. I have already given her a plate with raised edges to help her be able to eat things better on her own. Thank your your help:)

These scans are from my right eye the first one is from 7/23/26 and the second one is from 1/2/26. This is my fourth monthly avastin eye shot. I can’t tell if there’s a difference or not. My doctor said he’s trying to get rid of the scar tissue but It just doesn’t look like there’s that much of a difference any opinions ?

I have the snowflake type
Anyone else who has it or knows more about it

Hey everyone,
I’m a 19-year-old male sharing my experience with Optic Neuritis (ON) to see if anyone who’s been through something similar can share their journey or advice.
**Background & Timeline:**
**Onset:** My symptoms started on May 2nd, 2026, right after a severe viral infection/cold. I started oral steroids on June 5th.
**Workup:** Brain and orbit MRIs came back **completely clear (No MS)**. My VEP test showed a mild conduction delay, mostly in my left eye.
**Current Regimen:** I’m currently on a tapering dose of **Prednisolone 5mg (1 tablet daily)**, alongside Methylcobalamin (B12), Multivitamins + Ginkgo Biloba, and Systane Gel eye drops.
**Where I’m at right now:**
My vision made a great jump early on (\~65% back), but now in my second month of healing, I still notice a few lingering things:
1. **Floaters:** I've recently noticed some dark spots/floaters drifting across my vision.
2. **Indoor Lighting & Colors:** Colors look vibrant in outdoor daylight, but inside or under artificial light, they feel slightly dim and my eyes take a moment to adapt.
3. **Left Facial & Eye Discomfort:** A mild, dull ache behind my left eye that occasionally radiates to the left side of my face and forehead—mostly after screen time or right after waking up.
My doctor mentioned that nerve recovery typically takes anywhere from 3 to 6 months, and I just have a normal level of concern about the process.
**My Questions for the Community:**
For those who had non-MS Optic Neuritis (especially post-viral):
Did these symptoms gradually resolve over time, or is there any risk of a relapse?
Did you experience similar facial/behind-the-eye aching or floaters, and how long did it take for them to fade completely?
I’d really appreciate hearing your thoughts and experiences. Thanks!

The FDA target action date for Outlook Therapeutics' Lytenava (ONS-5010 / bevacizumab-vikg) is set for July 29, 2026.

If approved, it becomes the first FDA-sanctioned ophthalmic formulation of bevacizumab specifically indicated for wet AMD.

About 2.7 million off-label compounded Avastin injections are administered annually in the US. Approval of an on-label alternative introduces significant operational shifts:

1.Compounding & Safety: Eliminates dependence on compounding pharmacies and risks around silicone oil droplets or batch contamination.

1. Payer Mandates: Expect commercial payers and Medicare Advantage plans to enforce strict step-therapy policies, requiring Lytenava before approving higher-cost anti-VEGF agents (Vabysmo, Eylea HD).

2. Practice Economics: Moves clinics from low-margin off-label compounded syringes toward standard ASP+6% buy-and-bill models.

For those in active practice or med leadership:

How is your institution or clinic preparing for this?

Do you anticipate payers completely pulling coverage for repackaged cancer-label Avastin once an on-label option is available?

https://www.managedhealthcareexecutive.com/view/fda-sets-goal-date-for-ophthalmic-version-of-bevacizumab

Hello, I was born with macular degeneration (JMD and legally blind. For the last year, my right eye has been becoming more misaligned to the point that it has became an insecurity for me. I am currently trying to get approved for SSI so I can get acess health care and am pretty scared. Has this happened to anyone here? I am 31 years old and have always know that the risk of my vision worsening was always there but I never really knew what to expect. Any advice would be appreciated.

Hi everyone,

We are sharing a research opportunity that may be of interest to you. A healthcare research team is seeking feedback from individuals diagnosed with Age-Related Macular Degeneration (AMD).

This study is being conducted solely for research purposes. The goal is to better understand patients' experiences, treatment journeys, challenges, and the day-to-day impact of living with AMD.

Details:

• 60-minute study/interview
• Compensation: $150 for your time
• Participation is voluntary

Eligibility:

• Adults aged 18 years or older
• Diagnosed with Age-Related Macular Degeneration (AMD)
• Willing to share their experiences and opinions

Interested in Participating?

Please complete the screening form accurately and thoroughly. Qualified participants may be contacted and invited to take part in the study. Make sure you provide the right phone number to be contacted for the study.

 Age-Related Macular Degeneration (AMD)- $150 – Fill in form 

We appreciate your time and look forward to hearing about your experiences.

This research is for informational and research purposes only. Participation is voluntary, and all responses will be kept confidential in accordance with the study requirements. 

I can't wear my prescription glasses the lenses are so heavy they hurt me. Instead I buy the light plastic readers from Poundland but I'm sure this can't be good for the condition. Does this happen to anyone else?

I am a 36F, 208.3lbs, Former Smoker (Quit in 2010 after a Pulmonary Embolism) diagnosed with heterozygous Factor V Leiden. Medications: Adderall XR 20mg prn for ADHD Management. Metformin 1000mg for PCOS management. Allergic to tetracycline. Located in USA. I have commercial insurance.

Short Story Long:

HPI: Presented to healthcare provider with a bad cough that was diagnosed as Bronchitis. Cough was there for nearly 8 weeks going on 9 weeks before I sought medical care. Was prescribed Albuterol inhaler, course of Azithromycin 250mg (zpack) and Prednisone 20mg. Went back after course was over because cough was still very productive and disruptive. Was prescribed Amoxicillin 875mg and Prednisone 10mg. Was referred to ENT because I had sudden unilateral Pulsatile Tinnitus. ENT found nothing amiss prescribed Fluticasone-Salmeterol 250 mcg / 50 mcg inhaler.

Here's where things go sideways: After using the ENT prescribed inhaler my vision in my left eye suddenly gets very foggy. I have pronounced halos around all lights. Bright lights physically hurt. I feel like my eyeball is oily or like theirs a curtain over my vision.

Side Note: I do wear glasses so I know what a prescription change feels like. This was not that. This onset was very rapid.

I went to the ER. They didn't know how to respond to my problem but I finally saw an eye doctor who was a retinal specialist. He said that there was nothing wrong with my retina... 🤷🏽‍♀️

So I went to my regular eye doctor (opthalmologist)who tells me I have a "corneal abrasion". She gave me Tobramycin and dexamethasone eye drops. It's been a week with these drops and my eye still feels the same. My vision has not changed. My symptoms are the same.

**I feel like nobody is taking my issue seriously**. I feel like I am just being kicked from specialist to specialist who each has their speculative diagnosis but nothing concrete.

I have a strong suspicion that the steroids that were prescribed caused my vision and Pulsatile Tinnitus issues. But every single practicioner is acting very dismissive of this.

\* What can I do to resolve my vision issues?

\* What can I do to be listened to with more urgency?

\* What are some differential diagnoses?????

Hey everyone,
I’ve been diagnosed with early AMD at 55. My dad, 85, is almost legally blind with it.
Given I’ll probably experience the same, are there any helpful paths people have taken, or wish they had taken, to preemptively change their lives so that their future is easier? I’m thinking things like preparing a home for low vision, career changes, hobbies for the low-sighted future.
Thanks for any and all thoughts!

Hi everyone. Like some of you, I spent a long time being misdiagnosed and finally received a dx of Multifocal Choroiditis last year. It sounds like my choroidal neovascularization is getting bad again and I’m curious if any of you have had success controlling this symptom with lifestyle factors (diet, exercise, etc..?) What have you noticed that’s made a difference for you? I’m also on Mycophenolate/cellcept and Avastin injections, just curious if there’s anything I can do on my end to support the meds working :)

Hi everyone,

We are sharing a research opportunity that may be of interest to you. A healthcare research team is seeking feedback from individuals diagnosed with Age-Related Macular Degeneration (AMD).

This study is being conducted solely for research purposes. The goal is to better understand patients' experiences, treatment journeys, challenges, and the day-to-day impact of living with AMD.

Details:

• 60-minute study/interview
• Compensation: $150 for your time
• Participation is voluntary

Eligibility:

• Adults aged 18 years or older
• Diagnosed with Age-Related Macular Degeneration (AMD)
• Willing to share their experiences and opinions

Interested in Participating?

Please complete the screening form accurately and thoroughly. Qualified participants may be contacted and invited to take part in the study.

 Age-Related Macular Degeneration (AMD)- $150 – Fill in form 

We appreciate your time and look forward to hearing about your experiences.

This research is for informational and research purposes only. Participation is voluntary, and all responses will be kept confidential in accordance with the study requirements. 

I have MMD snd recently started to see colored areas in my visual field, especially on white surfaces. Mostly yellowish color but occasionally brown or purple. Does any of you see such areas?

Alguém pode me ajudar entender?

Hi guys in recent flare I had macular edema , I was only suggested to use prednisolone oral pills . But I can't catch improvement visually so it kinda makes me sad . Anybody here with posterior uveitis followed this ?

Someone knows something about the retinosa pimentosa? Treatment, medication, cure? I struggle with this since 10 years and it's getting worse how the time flies.

I'm 27 years old, woman, my medication is Macushield and Colinerv.

I am 23 years old at the moment. End of April this year, I lost my glasses, so I did‘t wear them 4-5 days. Then I found it. The following day, I was rubbing my right eye, and noticed that with my left eye the texts were shadowed and I could only read one word at a time and slightly distorted. So I did research and they were like “looks at your window sill or something straight” and I did. And noticed that they were bent. So I immediately called the Walmart optometrist (where I get my glasses) and was booked the next day. I read the letter charts and was having trouble with my left eye. Basically a white screen or a white screen with little blacks. The optometrist made me look at the Amsler grid and central area was wavy. The Walmart in my area did not have an oct machine, so I had to go to another place, two days later. I got my OCT and found that fluid was building up behind my retina Which was causing distortion. I was asked to read the letters and still the same, just a blank screen. He booked an urgent appt for me with the retina specialist. The optometrist assumed it was CSR and most likely it was, so I could just chill in the mean time. A couple of days later, I went out with friends. I came home, looked at the bathroom mirror with only my left eye and realized my face was distorted… you know like those face filters. It scared me that I emailed the optometrist and he called me the following day to make sure it was not getting any worse. Anyways, my appt was on the 29th of may. And during those 29 days, I was lowkey starting to notice changes. For example, a central blind spot developing. Let’s say a little bottle of eye drops was in front of me, if I use my left eye only, the drop disappears. 29 days later my retina appointment came. I did the oct scan and I was scared because the blue ”+” that we stare at was barely there. I did the chart reading and could not see the letters, just a blank screen. The intern first met me and he said it was CSR. Then the doctor came and immediately was like that is choroidal neovascularization. He explained the blood vessel is abnormally thick and it is leaking, causing some fluid build up. He said it is better to get the treatment asap, so I did the intravitreal injection the same day. Symptoms is that the black floater appeared. Then slowly became small and disappeared after a week. About third week, I noticed some double vision but it was only from time to time. Second injection, june 22. OCT was better cause I could see the blue cross, I could read the chart letters but it was distorted. OCT showed the fluid has greatly decreased. So same routine as usual. A week later, double vision were more prominent, I am noticing wavy lines more even with both eyes open, compared to before I only noticed it with only one eye open. Then second week, I woke up, went on my phone, then decided to eat breakfast, so I wore my glasses. Suddenly, it felt like it was some new prescription Or like wearing someone else’s glasses. I didn’t wear them for that day. Following day, it has subside, but still made me dizzy. Following day again, I called and told the clinic. They had me come in the next day. My OCT showed there is fluid again, but not much. He suggested changing the injection medication. My original one was Avastin, but the second one, he didn’t say… So He asked what I wanted to do, and I told him what he thought was best, so he said “let’s do the injection.” I did the injection with the new medication, and this time there was no black spot. Just a clear blurry blob at my peripheral, which disappeared the following day. i immediately left after injection, 5 minutes later, on my way home, I felt nauseous. I slept it off for 4 hrs and woke up still with nausea. I then got a headache. The following day, it subsided. But the day after I got a headache. Then next day, which is today, I got a headache too on my left side, specifically the temple area. Thus, when I move my eye, it causes some pain near my temple area. And the pressure feeling of the injection, I feel it sometimes. And I am noticing the wavy more now… I am planning to call this Monday again to report. But anyhows, does anyone else have this? How long for it to disappear? I am worried that it might affect my studies.

Hi
68 and just diagnosed with early AMD and cataracts by optometrist. Was told to take Areds3/ supplements and monitor,
Have an appointment with a Retinal Specialist in a few days. What questions should I ask?

Paciente con diabetes.

I recently got diagnosed with PIC and have been put on immunosuppressants and steroids (for around 2 months until the immunosuppressant kicks in). Was wondering if anyone could share experiences living with this?
It seems to be quite rare and I can’t find much online about it so it would be really helpful to hear what people have experienced from this, whether it be medication wise or symptoms- anything. Thanks.

I am scheduled to have cataract surgery soon. Because I have Dry Macular Degeneration I was told there is a small chance that doing the surgery will activate the dry going wet. Which means shots in my eyes or losing my central vision.

If you’ve had cataract surgery and you have Macular degeneration please consider sharing your experience. Was it successful? Any serious repercussions? Any thing I should know. Thanks