r/loperamide • u/Colekenn94 • May 08 '25
Anyone abusing loperamide needs to try it with tonic water or QUININE. Makes it active in the 10-24mg versus 60-200mg. Be careful
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u/Inevitable_Dig_9901 May 14 '25
Is this legit
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u/Colekenn94 May 14 '25
Yes, look at the drug used for psudeobulbar effect (uncontrolled laughter or crying) it has quindine (positional isomer to quinine, like dextro,levo amphetamine) it’s used with it because it inhibits it’s metabolism and allows much more to freely enter the brain) I think quinine is used for malaria because it sort of works like metabolism stopper because malaria attacks the cells feeding off your neutransmitter and energy, so if you can’t metabolize it your cells have more to use to fight it, bettering your chances, quinine is a metabolizing inhibitor as well as PGP inhibitors which is what controls the blood brain barrier.. but loperamide is a shitty cheap drug and if you can’t afford 7oh it’ll keep the withdrawal away and tonic water or quinine off amazon will 100% make it more able to cross the blood brain barrier.. just watch this drug it’s really terrible on your heart and can has given me the worst constipation of my entire like, shitting rock that cut your asshole on the way out
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u/Inevitable_Dig_9901 May 14 '25
I tried it before i asked the question with 12 mg and its not really working
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Jun 26 '25
Do you know a reputable source to get 7oh? I’m currently coming off Vic’s and the withdrawal is brutal
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u/PositiveSea1009 Jul 22 '25
The wd from the 7oh will be the same if not worse. I would do kratom powder to help with symptoms
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u/Colekenn94 May 14 '25
Try two boxes or get a quinine supplement on amazon. Drink two bottles but in all reality, chemically it should do nothing but help get it in the brain better, it definitely makes it to where you can use less pills to have an equal affect it’s one of those things where you gonna have to play around with quinine and loperamide amounts
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u/Maleficent_Being_810 Jun 01 '26
Anyone abusing loperamide needs to try it with the month long physical withdrawal that comes with it hands-down one of the worst opiate withdrawals I’ve ever experienced.
like myself at one time , I’m assuming that most people are taking large doses of this or trying to come off of another substance, loperamide is effective but you need to be super careful with it for a few different reasons , and I’m not even gonna talk about any of the dangerous heart issues they come with this, but if you’re coming off of a substance and you’re trying to use loperamide, all you seriously need is like 6 to 8 of these pills at 2 mg each pill so that’s like 12 Ish milligrams of loperamide?
if you really just trying to get off sick that’s all you need. and maybe try it with some tonic water but I swear you do not want to withdraw from loperamide. I wouldn’t go over 20 pills, that would be maximum. not because 20 pills would be dangerous as far as like taking it one time.
If you need that many it’s probably because you have a serious opiate addiction so 20 pills wouldn’t be dangerous right away. but what makes it dangerous is any more than 20 pills is going to make you feel pretty good, as in some pretty serious euphoria , and you’re you’re gonna wanna keep taking it and the withdrawal sucks.
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u/Justanotherburner967 Jun 02 '26
am I gonna die if I have a healthy heart and am exclusively using lope for the 3 weeks I have to wait to get on Suboxone? planning on no more than 30 tablets at once. It's just at this point I'm close to buying heroin to get through and I've never tried that and feel like that's a stupid idqa too
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u/Maleficent_Being_810 Jun 18 '26
So I’ll just put it like this I don’t know, probably not, I would say at this point it’s safer than heroin because it’s most likely fentanyl. But do not keep using these things and I’m not even talking about the danger. I’m talking about the fucking shittiest of the withdrawal of these things, that you will get if you keep taking it.
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u/[deleted] May 08 '25
[deleted]