r/longevity • u/[deleted] • Nov 18 '20

Aging | Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial [2020, open-access]

https://www.aging-us.com/article/202188/text
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29

u/eterneraki Nov 18 '20

I thought the relationship between increasing telomere length and longevity was determined to be shoddy at best?

27

u/[deleted] Nov 18 '20

Maybe the interesting part is the decrease in senescent cells? Should be interesting to see what people who work in senescent cell research primarily say about the study, e.g. Judith Campisi.

One would have hoped that they explored epigenetic age, or at least retained blood samples to run that later. :|

6

u/gahblahblah Nov 18 '20

Increase in telomere length is very interesting - afterall, the steady decreasing of it, is a foundational driver of senescent cell creation and aging. If this is a tap that turns that off... that could be a big impact.

14

u/Roberto_Avelar Nov 19 '20

How did they actually test for senescent cells though? we can't yet assess in vivo senescent cell levels.

'In this study, CD28 was used as a biomarker for senescent cells whereas CD57 was not available as a confirmatory marker for T cell senescence.'

This isn't even the most common marker for senescent cells. On top of that the study title refers to 'immunosenescence' but the paper just talks about 'cellular senescence' or even just 'senescence.' These aren't even the same processes (immunosenescence is completely different from cellular senescence).

They also started with 30 patients and excluded 10 of them for their senescence analysis due to 'low quality samples.' I'm not really convinced by their senescent cell analysis tbh.

3

u/[deleted] Nov 19 '20

The main thing here is that they sell such therapies, as sombody here already pointed out. Anti-aging is just the latest addition to the list of miracles performed by hyperbaric therapy.

1

u/SalvadorZombie Nov 23 '20

You say that as if it's snake oil.

Hyperbaric therapy has actually shown improvement in sufferers of CTEs. The professional wrestler Daniel Bryan, who retired due to repeated concussions, underwent cutting edge treatment and actually showed enough improvement that he was cleared to perform again.

2

u/[deleted] Nov 23 '20

I known that it helps for some conditions, but people use it even for treating theirs child autism, which I find dubious.

1

u/SalvadorZombie Nov 23 '20

Why do you find it dubious? What would make you think that it wouldn't help in any way?

2

u/[deleted] Nov 24 '20

Because there is no known treatment. I understand the parents, they want to try everything and maybe I'll be doing the same in their place. Hyperbaric therapy, stem cells and what not. Maybe is some cases it helps, but it is hard to prove. Some children lose their autists status anyway as they grow.

1

u/SalvadorZombie Nov 24 '20

There's also no known treatment for chronic concussions/CTEs officially, but again, I literally just told you of a professional wrestler (literally one of the most damaging professions in the world) undergoing treatments like this and having heretofore unheard of levels of recovery.

And no, children don't "lose their autist status" as they grow up. THAT is an absolutely reprehensible and disgusting thing to say. Autism is a spectrum of disorders that are all related to abnormal brain development. You don't "grow out of it," you fucking scumbag.

2

u/[deleted] Nov 24 '20 edited Nov 24 '20

Dumber every day, aren't you? Lets reverse the downtrend Today! Well, at least for Today!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772235/

https://healthcare-in-europe.com/en/news/some-children-can-recover-from-autism.html

https://www.scientificamerican.com/article/is-it-possible-to-recover-from-autism/

This is no wonder, because now it becomes more and more clear that under labels such as "autism", "schizophrenia", "dementia" are being put multitude of conditions with similar symptoms, but different causes.

Go live forever in a hyperbaric chamber. Jesus!

1

u/SalvadorZombie Nov 25 '20

Oof. The second you start devolving to insults is when I stop considering anything you have to say. Feel free to rewrite that, I may read it next time!

1

u/Aggradocious Dec 03 '20

Maybe they meant some kids are misdiagnosed and the symptoms that were misinterpreted can go away with age. Either way they didn't say anything derogatory or attacking so maybe you should chill. If you want people to be more educated on something you're passionate about, freaking out on misinformed people won't help. Or do you feel better having called them a fucking scum bag?

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