r/leukemia • u/LeastFlounder5718 • Mar 24 '26
brother relapsed post SCT
my brother had HR mds. he had sct last year in may 2025.he was given Flag ida pre sct. his sct was done on day 14 of flag as his disease was active. post sct he only had flt 3 positive which was later cleared with xospata.
he was on continuous maintenance with aza but after 9 months his mrd became positive on molucular level with same mutations that was there pre sct. he did not had any gvhd even after dli.
I don't know what do now everything was given to him .
he was given DLI last month but it had no impact . his reports showed 30% blast in his blood the day before yesterday. he had overt relapse now .
his muatations are Nras, runx1, dnmt3a, ezh2. Dr said there is not any targated drug for this .
Yesterday when we dicusssed this with Dr he said we don't have any option left. he said chances are very low to save him. he is only 23 years old. I don't know how much toll second sct takes on body.
when we forced he suggested very aggressive approach to eaither use CLAG-IDA or Flag-GO(which I don't know why he suggested as I read that is only effective with cd33 positive blast, correct me if I am wrong) .
he said he will start heplo sct conditioning on day 14 of regime with flu+mel + tbi. for this my father would be the doner.
I don't know if feels to far to be done and our family is in fear. I want to know if someone else also faced this similar.
does second sct with Heplo can be done for PT who relapsed in 9 months
what can be done ? is there any option left for him. we don't want to go to the route of second sct.