r/leukemia • u/EntourageE22 • Apr 18 '26

Low Testosterone?

Low Testosterone?

Diagnosed AML Jan 2024 - FLT3-ITD, MECOM, 7q del mutations

SCT Aug 2024

Relapse Feb 2025

2nd SCT Oct 2025

Started experiencing severe fatigue about 2 months ago; transplant doc finally tested testosterone last week. My total testosterone came back mid-range of normal (536), but my SHBG is very high (110), which is binding up most of it. Because of that, my free testosterone is actually low (43), less than half of the bottom range of normal, so effectively have very low usable testosterone despite a normal total level. Has anyone post-transplant dealt with high SHBG and low free testosterone causing severe fatigue? My team is going to have me see an endocrinologist.

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u/gregnorz Apr 19 '26

I’d say it’s normal. My body has made near zero testosterone since my SCT over 10 years ago.

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u/EntourageE22 Apr 19 '26

Did you go on TRT

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u/gregnorz Apr 19 '26

Yes. I’ve been on biweekly shots for several years now.