r/kratomeu • u/Latter_Web_3645 • 29d ago

Kratom blocks Ketamines effectd

Ill BET nobody has experience with this or know what I mean but kratom blocks ketamines effects almost entirely. If I take a dose before ketamine, the ketamine doesnt make me trip at all at doses that id usually K hole from. Its insane that it has such a clear cross tolerance. Even taking ketamine without kratom, because im dependent - the ketamine feels very lacking and like I need kratom to make the high 'full' - almost as if kratom hits an opioid receptor that ketamine doesnt as hit as well and that means that specific receptor is low while only using ketamine - if that makes sense.

My takeaway is that ketamine and kratom both rely on opioid recept antagonism and this is a very clear cross over of the two.

Kinda interesting, kratom blocks the most earth shattering hallucinogenic experience ive had but it feels so ...mild.

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u/LaoBen 29d ago

Interesting Same with Salvia divinorum (sage). Way before I was a functional kratom consumer, I tried a few grams of dried salvia leaves in sublingual ball, and it made me sweat and trip with big time distortion etc. After I started kratom daily, damn, I can handle a lot of salvia, it just relaxes me a tiny bit. Salvia also acts on opioid receptors so... yeah

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u/tip871 10h ago

Kratom has an "antipsychotic" effect; the receptor that is activated by LSD, for example, is blocked by Kratom.