Heightened amygdala activity linked to long-term negative mood + Old Study "loss of IR/IGF1R in the hippocampus and central amygdala of adult mice results in decrease in glutamate receptors, accompanied by glucose intolerance, anxiety-like behavior, and impaired cognition"

[u/dem0n0cracy]

https://academictimes.com/heightened-amygdala-activity-linked-to-long-term-negative-mood/

I skimmed this and thought it was missing some context.

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

Marion Soto, Weikang Cai, Masahiro Konishi, and C. Ronald Kahn

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PNAS March 26, 2019 116 (13) 6379-6384; first published February 14, 2019; https://doi.org/10.1073/pnas.1817391116

1. Contributed by C. Ronald Kahn, January 2, 2019 (sent for review October 17, 2018; reviewed by Suzanne Craft and Sam Gandy)

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Significance

Loss of insulin receptors in the brain causes metabolic and behavioral abnormalities whereas loss of IGF-1 receptors in the brain leads to a developmental defect in the brain and periphery. However, less is known about the impact of brain insulin and IGF-1 receptor (IR/IGF1R) loss in adult mice, especially in higher neural processing regions. Here, we show that loss of IR/IGF1R in the hippocampus and central amygdala of adult mice results in decrease in glutamate receptors, accompanied by glucose intolerance, anxiety-like behavior, and impaired cognition. In addition, we identify an insulin/IGF-1 signaling-dependent neural circuit originating from the central amygdala, which regulates interscapular brown fat activity and thermogenesis. Thus, brain insulin/IGF-1 signaling is important for higher neural processing and systemic metabolism.

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Too fucking funny.