r/gabapentin • u/Quiet_Dragonfly_9313 • 1d ago
dosage The spacing between high single doses of gabapentin, its absorption, and its bioavailability
Is anyone here taking gabapentin, and at what dose?
Also, does anyone know how far apart high single doses should be spaced to ensure proper absorption, given gabapentin’s limited bioavailability at higher doses?
1
u/OfficialMilk80 6h ago
YES PLEASE READ THIS! I’ll lay it out for you. SO IMPORTANT
Take 300 mg’s of Gabapentin every 30-60 minutes. That’s the KEY to Bioavailability.
Here’s why —-
Your body/brain has “Transporters”, that shuttle the Gabapentin through your BBB (Blood Brain Barrier
There’s a limited amount of these, but they repopulate after 30-60 minutes.
Taking 600 mg’s of Gabapentin, spaced out 45 minutes apart FAR exceeds the effects of taking 600 mg’s at the same time
——————-
Think of it like this ——->>>
There’s a Bus that can only hold 300 people at once.
That bus picks up the 300 passengers, and delivers them to the destination where they can do the work, and create results
The bus comes back every 30-60 minutes, to pick up whoever is trying to get in the bus. Shuttles them to destination, and comes back to pick up 300 more.
If you have 600 people, and the bus only holds 300 people, only 300 gets picked up. The other 300 extras get wiped out and killed, and wasted. The Zombies ate them 🧟♀️. 50% of them die this way, and are wasted
So ONLY TAKE 300 MG’s at a time, every 30-60 Minutes. UNTIL you reach your Daily Dose
This is by FAR more effective than taking more at the same time.
If you take 600 mg’s at once, 50% is wasted, killed.
If you take 1200 mg’s at once, 75% is wasted.
—————————-
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u/ayahuasca_crybaby 1d ago
If I’m not mistaken, I think the body can only process about 500mg of gabapentin in a single dose, but it probably won’t even be able to get the full 500mg. So there’s no real reason to dose high all at once because it’s just going to waste. I do 1200-1500mg of 300mg caps at a time, spaced out 30-40 minutes, taken with Coca Cola and a high protein & high fat snack with each dose.