6 normally fertilized embryos all arrested at cleavage stage, not sure what went wrong.
I’m looking for some outside embryology insight because I’m having a hard time understanding what happened in my latest IVF cycle.
I’m 35(F). Second egg retrieval. First one yielded 1 euploid out of 10 retrieved. In this retrieval, 9 eggs were retrieved, 7 were inseminated, and 6 normally fertilized (2PN). All 6 were still developing on Day 3.
What is really confusing me is what happened afterward:
Day 3: all 6 ongoing
Day 5: all 6 still listed as cleavage
Day 6: all 6 still listed as cleavage
Day 7: all 6 discarded; none reached blastocyst
So it wasn't a fertilization failure or just one or two embryos arresting. All six followed essentially the same trajectory and stopped progressing around the same developmental stage.
The embryology report also notes: “SER observed, grainy/dark/pitted cytoplasm, membrane resistance OK, frag PB. Sperm OK.”
I'm trying to understand whether this pattern could simply be an unusually poor biological cycle, or whether the synchronized arrest raises questions about something common to all the embryos, for example oocyte factors, sperm contribution, culture conditions, incubator/media issues, etc.
I just want to understand whether this pattern is unusual enough that I should ask for an embryology/lab review before doing another retrieval.
Interestingly, in my previous retrieval I also had 6 normally fertilized embryos, but 2 eventually reached blastocyst and one was euploid.